Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors

Wenjun Du; Jacquelyn Gervay-Hague

doi:10.1021/ol050659f

Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors

Wenjun Du, Jacquelyn Gervay-Hague

Chemistry

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

(Chemical Equation Presented) The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to α GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.

Original language	English (US)
Pages (from-to)	2063-2065
Number of pages	3
Journal	Organic Letters
Volume	7
Issue number	10
DOIs	https://doi.org/10.1021/ol050659f
State	Published - May 12 2005

ASJC Scopus subject areas

Molecular Medicine

Access to Document

10.1021/ol050659f

Fingerprint Dive into the research topics of 'Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors'. Together they form a unique fingerprint.

Cite this

@article{810283df30f842d789608410d1092225,

title = "Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors",

abstract = "(Chemical Equation Presented) The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to α GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.",

author = "Wenjun Du and Jacquelyn Gervay-Hague",

year = "2005",

month = may,

day = "12",

doi = "10.1021/ol050659f",

language = "English (US)",

volume = "7",

pages = "2063--2065",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors

AU - Du, Wenjun

AU - Gervay-Hague, Jacquelyn

PY - 2005/5/12

Y1 - 2005/5/12

N2 - (Chemical Equation Presented) The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to α GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.

AB - (Chemical Equation Presented) The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to α GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.

UR - http://www.scopus.com/inward/record.url?scp=19544385277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19544385277&partnerID=8YFLogxK

U2 - 10.1021/ol050659f

DO - 10.1021/ol050659f

M3 - Article

C2 - 15876055

AN - SCOPUS:19544385277

VL - 7

SP - 2063

EP - 2065

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 10

ER -