Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors

Wenjun Du, Jacquelyn Gervay-Hague

Research output: Contribution to journal › Article

93 Citations (Scopus)

Abstract

(Chemical Equation Presented) The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to α GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.

Original languageEnglish (US)
Pages (from-to)2063-2065
Number of pages3
JournalOrganic Letters
Volume7
Issue number10
DOIs
StatePublished - May 12 2005

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Galactosylceramides
Iodides
iodides
Electrons
analogs
Lipids
synthesis
lipids
routes
electrons

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors. / Du, Wenjun; Gervay-Hague, Jacquelyn.

In: Organic Letters, Vol. 7, No. 10, 12.05.2005, p. 2063-2065.

Research output: Contribution to journal › Article

Du, W & Gervay-Hague, J 2005, 'Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors', Organic Letters, vol. 7, no. 10, pp. 2063-2065. https://doi.org/10.1021/ol050659f
Du W, Gervay-Hague J. Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors. Organic Letters. 2005 May 12;7(10):2063-2065. https://doi.org/10.1021/ol050659f
Du, Wenjun ; Gervay-Hague, Jacquelyn. / Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors. In: Organic Letters. 2005 ; Vol. 7, No. 10. pp. 2063-2065.
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