Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors

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Abstract

(Chemical Equation Presented) The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to α GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.

Original languageEnglish (US)
Pages (from-to)2063-2065
Number of pages3
JournalOrganic Letters
Volume7
Issue number10
DOIs
StatePublished - May 12 2005

ASJC Scopus subject areas

  • Molecular Medicine

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