Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP)

Musleh M. Muthana, Jingyao Qu, Yanhong Li, Lei Zhang, Hai Yu, Li Ding, Hamed Malekan, Xi Chen

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

A promiscuous UDP-sugar pyrophosphorylase (BLUSP) was cloned from Bifidobacterium longum strain ATCC55813 and used efficiently with a Pasteurella multocida inorganic pyrophosphatase (PmPpA) with or without a monosaccharide 1-kinase for one-pot multienzyme synthesis of UDP-galactose, UDP-glucose, UDP-mannose, and their derivatives. Further chemical diversification of a UDP-mannose derivative resulted in the formation of UDP-N-acetylmannosamine. This journal is

Original languageEnglish (US)
Pages (from-to)2728-2730
Number of pages3
JournalChemical Communications
Volume48
Issue number21
DOIs
StatePublished - Mar 11 2012

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

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