Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetetraminepentaacetic acid

Donald T. Corson, Claude F. Meares

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We have developed and optimized the synthesis of the title compound, eliminating all HPLC purifications prior to the final product. The yield (and scale) of the synthesis was increased from 19% (200 mg) to 75% (26 g).

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalBioconjugate Chemistry
Volume11
Issue number2
DOIs
StatePublished - Mar 2000

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Chelating Agents
Chelation
High Pressure Liquid Chromatography
Acids
Purification

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetetraminepentaacetic acid. / Corson, Donald T.; Meares, Claude F.

In: Bioconjugate Chemistry, Vol. 11, No. 2, 03.2000, p. 292-299.

Research output: Contribution to journalArticle

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