Efficient enzymatic synthesis of guanosine 5′-diphosphate-sugars and derivatives

Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao, Peng George Wang

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

An N-acetylhexosamine 1-kinase from Bifidobacterium infantis (NahK-15697), a guanosine 5′-diphosphate (GDP)-mannose pyrophosphorylase from Pyrococcus furiosus (PFManC), and an Escherichia coli inorganic pyrophosphatase (EcPpA) were used efficiently for a one-pot three-enzyme synthesis of GDP-mannose, GDP-glucose, their derivatives, and GDP-talose. This study represents the first facile and efficient enzymatic synthesis of GDP-sugars and derivatives starting from monosaccharides and derivatives.

Original languageEnglish (US)
Pages (from-to)5528-5530
Number of pages3
JournalOrganic Letters
Volume15
Issue number21
DOIs
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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