Abstract
An N-acetylhexosamine 1-kinase from Bifidobacterium infantis (NahK-15697), a guanosine 5′-diphosphate (GDP)-mannose pyrophosphorylase from Pyrococcus furiosus (PFManC), and an Escherichia coli inorganic pyrophosphatase (EcPpA) were used efficiently for a one-pot three-enzyme synthesis of GDP-mannose, GDP-glucose, their derivatives, and GDP-talose. This study represents the first facile and efficient enzymatic synthesis of GDP-sugars and derivatives starting from monosaccharides and derivatives.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5528-5530 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 15 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 1 2013 |
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
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Cite this
Li, L., Liu, Y., Wan, Y., Li, Y., Chen, X., Zhao, W., & Wang, P. G. (2013). Efficient enzymatic synthesis of guanosine 5′-diphosphate-sugars and derivatives. Organic Letters, 15(21), 5528-5530. https://doi.org/10.1021/ol402585c