Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

Li Ding, Hai Yu, Kam Lau, Yanhong Li, Saddam Muthana, Junru Wang, Xi Chen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

An N-terminal and C-terminal truncated recombinant α2-6- sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15-501)-His 6, was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.

Original languageEnglish (US)
Pages (from-to)8691-8693
Number of pages3
JournalChemical Communications
Volume47
Issue number30
DOIs
StatePublished - Aug 14 2011

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His-His-His-His-His-His
Sialyltransferases
N-Acetylneuraminic Acid
Antigens
Enzymes
Derivatives
Catalysts
Acids
sialosyl-Tn antigen

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives. / Ding, Li; Yu, Hai; Lau, Kam; Li, Yanhong; Muthana, Saddam; Wang, Junru; Chen, Xi.

In: Chemical Communications, Vol. 47, No. 30, 14.08.2011, p. 8691-8693.

Research output: Contribution to journalArticle

Ding, L, Yu, H, Lau, K, Li, Y, Muthana, S, Wang, J & Chen, X 2011, 'Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives', Chemical Communications, vol. 47, no. 30, pp. 8691-8693. https://doi.org/10.1039/c1cc12732b
Ding L, Yu H, Lau K, Li Y, Muthana S, Wang J et al. Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives. Chemical Communications. 2011 Aug 14;47(30):8691-8693. https://doi.org/10.1039/c1cc12732b
Ding, Li ; Yu, Hai ; Lau, Kam ; Li, Yanhong ; Muthana, Saddam ; Wang, Junru ; Chen, Xi. / Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives. In: Chemical Communications. 2011 ; Vol. 47, No. 30. pp. 8691-8693.
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