Abstract
Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α2-3-sialyltransferase or an α2-6-sialyltransferase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10310-10313 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 51 |
| Issue number | 51 |
| DOIs | |
| State | Published - Jun 28 2015 |
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ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Cite this
Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms. / Li, Lei; Liu, Yonghui; Li, Tiehai; Wang, Wenjun; Yu, Zaikuan; Ma, Cheng; Qu, Jingyao; Zhao, Wei; Chen, Xi; Wang, Peng G.
In: Chemical Communications, Vol. 51, No. 51, 28.06.2015, p. 10310-10313.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms
AU - Li, Lei
AU - Liu, Yonghui
AU - Li, Tiehai
AU - Wang, Wenjun
AU - Yu, Zaikuan
AU - Ma, Cheng
AU - Qu, Jingyao
AU - Zhao, Wei
AU - Chen, Xi
AU - Wang, Peng G.
PY - 2015/6/28
Y1 - 2015/6/28
N2 - Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α2-3-sialyltransferase or an α2-6-sialyltransferase.
AB - Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α2-3-sialyltransferase or an α2-6-sialyltransferase.
UR - http://www.scopus.com/inward/record.url?scp=84935891163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84935891163&partnerID=8YFLogxK
U2 - 10.1039/c5cc03746h
DO - 10.1039/c5cc03746h
M3 - Article
C2 - 26023910
AN - SCOPUS:84935891163
VL - 51
SP - 10310
EP - 10313
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 51
ER -