Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms

Lei Li, Yonghui Liu, Tiehai Li, Wenjun Wang, Zaikuan Yu, Cheng Ma, Jingyao Qu, Wei Zhao, Xi Chen, Peng G. Wang

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α2-3-sialyltransferase or an α2-6-sialyltransferase.

Original languageEnglish (US)
Pages (from-to)10310-10313
Number of pages4
JournalChemical Communications
Volume51
Issue number51
DOIs
StatePublished - Jun 28 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Li, L., Liu, Y., Li, T., Wang, W., Yu, Z., Ma, C., Qu, J., Zhao, W., Chen, X., & Wang, P. G. (2015). Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms. Chemical Communications, 51(51), 10310-10313. https://doi.org/10.1039/c5cc03746h