Abstract
Galacto-N-biose (GNB) derivatives were efficiently synthesized from galactose derivatives via a one-pot two-enzyme system containing two promiscuous enzymes from Bifidobacterium infantis: a galactokinase (BiGalK) and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase (BiGalHexNAcP). Mono-sialyl and di-sialyl galacto-N-biose derivatives were then prepared using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α2-3-sialyltransferase or an α2-6-sialyltransferase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10310-10313 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 51 |
| Issue number | 51 |
| DOIs | |
| State | Published - Jun 28 2015 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Cite this
Li, L., Liu, Y., Li, T., Wang, W., Yu, Z., Ma, C., Qu, J., Zhao, W., Chen, X., & Wang, P. G. (2015). Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms. Chemical Communications, 51(51), 10310-10313. https://doi.org/10.1039/c5cc03746h