Efficacy of tulathromycin for treatment of cattle with acute ocular Moraxella bovis infections

V Michael Lane, Lisle W. George, Dawn M. Cleaver

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective - To evaluate the clinical efficacy of a single injection of tulathromycin, compared with saline (0.9% NaCl) solution-treated control calves, for treatment of induced infectious bovine keratoconjunctivitis in calves. Design - Clinical trial. Animals - 30 Holstein bull calves ranging from 5 to 6 months old and 75 to 200 kg (165 to 440 lb) with no history of Moraxella bovis infections, no history of M bovis vaccination, and negative results for M bovis on 3 consecutive ocular bacterial cultures. Procedures - Both eyes of each calf were infected with 1 × 1010 colony-forming units of piliated M bovis for 3 consecutive days prior to the trial. On day 0, ocular lesion scores were determined for each calf and the calves were weighed and assigned to a treatment (2.5 mg/kg [1.14 mg/lb] of body weight, SC) or control group according to a stratified random allocation based on weight and lesion score. Eyes were stained with fluorescein and photographed daily to record healing. Eyes were evaluated bacteriologically for M bovis on days 0 to 6 and at 3-day intervals thereafter. Results - Median time to ulcer resolution in calves treated with tulathromycin was 9.1 days. More than 50% of control calves still had ulcers at the end of the trial (21 days). Moraxella sp was isolated less often from the eyes of treated calves than from the control calves. By day 10, the treated calves had lower ocular lesion scores than control calves. Conclusions and Clinical Relevance - A single dose of tulathromycin (SC) was an effective treatment of calves with experimentally induced infectious bovine keratoconjunctivitis. The long serum half-life of tulathromycin, along with the results of this trial, suggests that tulathromycin may be a rational choice as a single-injection treatment for infectious bovine keratoconjunctivitis.

Original languageEnglish (US)
Pages (from-to)557-561
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume229
Issue number4
DOIs
StatePublished - Aug 15 2006

Fingerprint

Moraxellaceae Infections
Moraxella (Moraxella) bovis
Moraxella bovis
eyes
calves
Infectious Keratoconjunctivitis
cattle
infection
keratoconjunctivitis
Ulcer
lesions (animal)
Moraxella
Injections
Therapeutics
Random Allocation
tulathromycin
Fluorescein
Half-Life
Vaccination
Stem Cells

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Efficacy of tulathromycin for treatment of cattle with acute ocular Moraxella bovis infections. / Lane, V Michael; George, Lisle W.; Cleaver, Dawn M.

In: Journal of the American Veterinary Medical Association, Vol. 229, No. 4, 15.08.2006, p. 557-561.

Research output: Contribution to journalArticle

@article{ee266efa2c484004b86e525a28ccb4e1,
title = "Efficacy of tulathromycin for treatment of cattle with acute ocular Moraxella bovis infections",
abstract = "Objective - To evaluate the clinical efficacy of a single injection of tulathromycin, compared with saline (0.9{\%} NaCl) solution-treated control calves, for treatment of induced infectious bovine keratoconjunctivitis in calves. Design - Clinical trial. Animals - 30 Holstein bull calves ranging from 5 to 6 months old and 75 to 200 kg (165 to 440 lb) with no history of Moraxella bovis infections, no history of M bovis vaccination, and negative results for M bovis on 3 consecutive ocular bacterial cultures. Procedures - Both eyes of each calf were infected with 1 × 1010 colony-forming units of piliated M bovis for 3 consecutive days prior to the trial. On day 0, ocular lesion scores were determined for each calf and the calves were weighed and assigned to a treatment (2.5 mg/kg [1.14 mg/lb] of body weight, SC) or control group according to a stratified random allocation based on weight and lesion score. Eyes were stained with fluorescein and photographed daily to record healing. Eyes were evaluated bacteriologically for M bovis on days 0 to 6 and at 3-day intervals thereafter. Results - Median time to ulcer resolution in calves treated with tulathromycin was 9.1 days. More than 50{\%} of control calves still had ulcers at the end of the trial (21 days). Moraxella sp was isolated less often from the eyes of treated calves than from the control calves. By day 10, the treated calves had lower ocular lesion scores than control calves. Conclusions and Clinical Relevance - A single dose of tulathromycin (SC) was an effective treatment of calves with experimentally induced infectious bovine keratoconjunctivitis. The long serum half-life of tulathromycin, along with the results of this trial, suggests that tulathromycin may be a rational choice as a single-injection treatment for infectious bovine keratoconjunctivitis.",
author = "Lane, {V Michael} and George, {Lisle W.} and Cleaver, {Dawn M.}",
year = "2006",
month = "8",
day = "15",
doi = "10.2460/javma.229.4.557",
language = "English (US)",
volume = "229",
pages = "557--561",
journal = "Journal of the American Veterinary Medical Association",
issn = "0003-1488",
publisher = "American Veterinary Medical Association",
number = "4",

}

TY - JOUR

T1 - Efficacy of tulathromycin for treatment of cattle with acute ocular Moraxella bovis infections

AU - Lane, V Michael

AU - George, Lisle W.

AU - Cleaver, Dawn M.

PY - 2006/8/15

Y1 - 2006/8/15

N2 - Objective - To evaluate the clinical efficacy of a single injection of tulathromycin, compared with saline (0.9% NaCl) solution-treated control calves, for treatment of induced infectious bovine keratoconjunctivitis in calves. Design - Clinical trial. Animals - 30 Holstein bull calves ranging from 5 to 6 months old and 75 to 200 kg (165 to 440 lb) with no history of Moraxella bovis infections, no history of M bovis vaccination, and negative results for M bovis on 3 consecutive ocular bacterial cultures. Procedures - Both eyes of each calf were infected with 1 × 1010 colony-forming units of piliated M bovis for 3 consecutive days prior to the trial. On day 0, ocular lesion scores were determined for each calf and the calves were weighed and assigned to a treatment (2.5 mg/kg [1.14 mg/lb] of body weight, SC) or control group according to a stratified random allocation based on weight and lesion score. Eyes were stained with fluorescein and photographed daily to record healing. Eyes were evaluated bacteriologically for M bovis on days 0 to 6 and at 3-day intervals thereafter. Results - Median time to ulcer resolution in calves treated with tulathromycin was 9.1 days. More than 50% of control calves still had ulcers at the end of the trial (21 days). Moraxella sp was isolated less often from the eyes of treated calves than from the control calves. By day 10, the treated calves had lower ocular lesion scores than control calves. Conclusions and Clinical Relevance - A single dose of tulathromycin (SC) was an effective treatment of calves with experimentally induced infectious bovine keratoconjunctivitis. The long serum half-life of tulathromycin, along with the results of this trial, suggests that tulathromycin may be a rational choice as a single-injection treatment for infectious bovine keratoconjunctivitis.

AB - Objective - To evaluate the clinical efficacy of a single injection of tulathromycin, compared with saline (0.9% NaCl) solution-treated control calves, for treatment of induced infectious bovine keratoconjunctivitis in calves. Design - Clinical trial. Animals - 30 Holstein bull calves ranging from 5 to 6 months old and 75 to 200 kg (165 to 440 lb) with no history of Moraxella bovis infections, no history of M bovis vaccination, and negative results for M bovis on 3 consecutive ocular bacterial cultures. Procedures - Both eyes of each calf were infected with 1 × 1010 colony-forming units of piliated M bovis for 3 consecutive days prior to the trial. On day 0, ocular lesion scores were determined for each calf and the calves were weighed and assigned to a treatment (2.5 mg/kg [1.14 mg/lb] of body weight, SC) or control group according to a stratified random allocation based on weight and lesion score. Eyes were stained with fluorescein and photographed daily to record healing. Eyes were evaluated bacteriologically for M bovis on days 0 to 6 and at 3-day intervals thereafter. Results - Median time to ulcer resolution in calves treated with tulathromycin was 9.1 days. More than 50% of control calves still had ulcers at the end of the trial (21 days). Moraxella sp was isolated less often from the eyes of treated calves than from the control calves. By day 10, the treated calves had lower ocular lesion scores than control calves. Conclusions and Clinical Relevance - A single dose of tulathromycin (SC) was an effective treatment of calves with experimentally induced infectious bovine keratoconjunctivitis. The long serum half-life of tulathromycin, along with the results of this trial, suggests that tulathromycin may be a rational choice as a single-injection treatment for infectious bovine keratoconjunctivitis.

UR - http://www.scopus.com/inward/record.url?scp=33748549939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748549939&partnerID=8YFLogxK

U2 - 10.2460/javma.229.4.557

DO - 10.2460/javma.229.4.557

M3 - Article

C2 - 16910856

AN - SCOPUS:33748549939

VL - 229

SP - 557

EP - 561

JO - Journal of the American Veterinary Medical Association

JF - Journal of the American Veterinary Medical Association

SN - 0003-1488

IS - 4

ER -