Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine

Marie Anne Paradis, Gordon H. Vessie, John K. Merrill, C. Paul Dick, Camille Moore, George Charbonneau, M. Gottschalk, Janet I. MacInnes, Robert Higgins, K. R. Mittal, G. Girard, Jeffery J. Aramini, Jeffrey B. Wilson

Research output: Contribution to journalArticle

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Abstract

The efficacy of tilmicosin administered in the feed to control Actinobacillus pleuropneumoniae infections in pigs was evaluated through a multisite, multitrial study. For each of 6 trials, 48 pigs (stratified by weight and sex) were randomly assigned to 6 to 8 pens. Medicated feed containing tilmicosin (200 g/t and unmedicated feed were randomly assigned at the pen level and were provided ad libitum from day -7 to trial termination (day 14). Seeder pigs (inoculated intranasally with A. pleuropneumoniae serotype 1 and showing signs of clinical disease) were introduced to each pen on day 0. Rates of death, gross lesions, and culture of A. pleuropneumoniae at necropsy, clinical scores, average daily gain in weight, and average body temperature were compared between the medicated and unmedicated pigs. Compared with the unmedicated pigs, significantly fewer (P < 0.05) pigs given tilmicosin had lesions typical of A. pleuropneumoniae or had A. pleuropneumoniae isolated from their tissues at necropsy. Together with a significant reduction (P < 0.05) in the average percentage of pneumonic lung involvement (both visually and by weight), there were reductions in the numbers of pigs with moderate and severe pneumonic lung lesions and with A. pleuropneumoniae associated mortality. With tilmicosin treatment, the average daily weight gain, daily temperature, abdominal appearance, attitude, and respiration were also significantly better (P < 0.05). The results of this study demonstrate the in vivo effectiveness of tilmicosin (200 g/t) in controlling pleuropneumonia among swine experimentally infected with A. pleuropneumoniae.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalCanadian Journal of Veterinary Research
Volume68
Issue number1
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Actinobacillus Infections
Actinobacillus pleuropneumoniae
Swine
swine
infection
lungs
lesions (animal)
Lung
Weight Gain
necropsy
Actinobacillus pleuropneumoniae 1
Pleuropneumonia
medicated feeds
Mortality
tilmicosin
in vivo studies
Body Temperature
average daily gain
body temperature
breathing

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Paradis, M. A., Vessie, G. H., Merrill, J. K., Dick, C. P., Moore, C., Charbonneau, G., ... Wilson, J. B. (2004). Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine. Canadian Journal of Veterinary Research, 68(1), 7-11.

Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine. / Paradis, Marie Anne; Vessie, Gordon H.; Merrill, John K.; Dick, C. Paul; Moore, Camille; Charbonneau, George; Gottschalk, M.; MacInnes, Janet I.; Higgins, Robert; Mittal, K. R.; Girard, G.; Aramini, Jeffery J.; Wilson, Jeffrey B.

In: Canadian Journal of Veterinary Research, Vol. 68, No. 1, 01.01.2004, p. 7-11.

Research output: Contribution to journalArticle

Paradis, MA, Vessie, GH, Merrill, JK, Dick, CP, Moore, C, Charbonneau, G, Gottschalk, M, MacInnes, JI, Higgins, R, Mittal, KR, Girard, G, Aramini, JJ & Wilson, JB 2004, 'Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine', Canadian Journal of Veterinary Research, vol. 68, no. 1, pp. 7-11.
Paradis, Marie Anne ; Vessie, Gordon H. ; Merrill, John K. ; Dick, C. Paul ; Moore, Camille ; Charbonneau, George ; Gottschalk, M. ; MacInnes, Janet I. ; Higgins, Robert ; Mittal, K. R. ; Girard, G. ; Aramini, Jeffery J. ; Wilson, Jeffrey B. / Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine. In: Canadian Journal of Veterinary Research. 2004 ; Vol. 68, No. 1. pp. 7-11.
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