Efficacy of tailored computer-based neurorehabilitation for improvement of movement initiation in Parkinson's disease

E. A. Disbrow, K. A. Russo, C. I. Higginson, E. W. Yund, M. I. Ventura, Lin Zhang, Norika O Malhado-Chang, David L Woods, K. A. Sigvardt

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

While Parkinson's disease (PD) is considered a motor disorder, motor signs of PD can be exacerbated by cognitive dysfunction. We evaluated the efficacy of a computer-based cognitive rehabilitation training program designed to improve motor-related executive function. Thirty people with PD and 21 controls participated in the 10-day training. Training consisted of a two-phase button press task. First, subjects produced an externally cued (EC) digit sequence, typing numbers displayed on the computer screen. Second, subjects were prompted to generate the same sequence in the absence of the number display (internally represented sequence, IR). Sequence length was automatically adjusted to maintain 87% correct performance. Participants were evaluated before and after training using a fixed version of the training task, and generalization of training was assessed using measures involving IR motor sequencing, switching and activities of daily living. PD participants were divided into two groups, those who showed impairment in IR motor sequence production prior to training (N = 14) and those whose performance was similar to controls (N = 16). Following training the impaired PD group showed significantly greater reduction in sequence initiation and completion time and in error rate for IR conditions compared to the unimpaired PD and control groups. All groups improved on Trails B-A, and pre-training Trails B was identified as a predictor of training-based improvement in IR sequence completion time and error rate. Our findings highlight the importance of neurorehabilitation tailored to the specific cognitive deficits of the PD patient.

Original languageEnglish (US)
Pages (from-to)151-164
Number of pages14
JournalBrain Research
Volume1452
DOIs
StatePublished - May 3 2012

Fingerprint

Parkinson Disease
Executive Function
Activities of Daily Living
Neurological Rehabilitation
Rehabilitation
Education
Control Groups

Keywords

  • Adaptive training
  • Cognitive rehabilitation
  • Movement initiation
  • Parkinson's disease
  • Sequencing

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Efficacy of tailored computer-based neurorehabilitation for improvement of movement initiation in Parkinson's disease. / Disbrow, E. A.; Russo, K. A.; Higginson, C. I.; Yund, E. W.; Ventura, M. I.; Zhang, Lin; Malhado-Chang, Norika O; Woods, David L; Sigvardt, K. A.

In: Brain Research, Vol. 1452, 03.05.2012, p. 151-164.

Research output: Contribution to journalArticle

Disbrow, E. A. ; Russo, K. A. ; Higginson, C. I. ; Yund, E. W. ; Ventura, M. I. ; Zhang, Lin ; Malhado-Chang, Norika O ; Woods, David L ; Sigvardt, K. A. / Efficacy of tailored computer-based neurorehabilitation for improvement of movement initiation in Parkinson's disease. In: Brain Research. 2012 ; Vol. 1452. pp. 151-164.
@article{3751040769e54ba0ad148bf4ed5dcc4d,
title = "Efficacy of tailored computer-based neurorehabilitation for improvement of movement initiation in Parkinson's disease",
abstract = "While Parkinson's disease (PD) is considered a motor disorder, motor signs of PD can be exacerbated by cognitive dysfunction. We evaluated the efficacy of a computer-based cognitive rehabilitation training program designed to improve motor-related executive function. Thirty people with PD and 21 controls participated in the 10-day training. Training consisted of a two-phase button press task. First, subjects produced an externally cued (EC) digit sequence, typing numbers displayed on the computer screen. Second, subjects were prompted to generate the same sequence in the absence of the number display (internally represented sequence, IR). Sequence length was automatically adjusted to maintain 87{\%} correct performance. Participants were evaluated before and after training using a fixed version of the training task, and generalization of training was assessed using measures involving IR motor sequencing, switching and activities of daily living. PD participants were divided into two groups, those who showed impairment in IR motor sequence production prior to training (N = 14) and those whose performance was similar to controls (N = 16). Following training the impaired PD group showed significantly greater reduction in sequence initiation and completion time and in error rate for IR conditions compared to the unimpaired PD and control groups. All groups improved on Trails B-A, and pre-training Trails B was identified as a predictor of training-based improvement in IR sequence completion time and error rate. Our findings highlight the importance of neurorehabilitation tailored to the specific cognitive deficits of the PD patient.",
keywords = "Adaptive training, Cognitive rehabilitation, Movement initiation, Parkinson's disease, Sequencing",
author = "Disbrow, {E. A.} and Russo, {K. A.} and Higginson, {C. I.} and Yund, {E. W.} and Ventura, {M. I.} and Lin Zhang and Malhado-Chang, {Norika O} and Woods, {David L} and Sigvardt, {K. A.}",
year = "2012",
month = "5",
day = "3",
doi = "10.1016/j.brainres.2012.02.073",
language = "English (US)",
volume = "1452",
pages = "151--164",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Efficacy of tailored computer-based neurorehabilitation for improvement of movement initiation in Parkinson's disease

AU - Disbrow, E. A.

AU - Russo, K. A.

AU - Higginson, C. I.

AU - Yund, E. W.

AU - Ventura, M. I.

AU - Zhang, Lin

AU - Malhado-Chang, Norika O

AU - Woods, David L

AU - Sigvardt, K. A.

PY - 2012/5/3

Y1 - 2012/5/3

N2 - While Parkinson's disease (PD) is considered a motor disorder, motor signs of PD can be exacerbated by cognitive dysfunction. We evaluated the efficacy of a computer-based cognitive rehabilitation training program designed to improve motor-related executive function. Thirty people with PD and 21 controls participated in the 10-day training. Training consisted of a two-phase button press task. First, subjects produced an externally cued (EC) digit sequence, typing numbers displayed on the computer screen. Second, subjects were prompted to generate the same sequence in the absence of the number display (internally represented sequence, IR). Sequence length was automatically adjusted to maintain 87% correct performance. Participants were evaluated before and after training using a fixed version of the training task, and generalization of training was assessed using measures involving IR motor sequencing, switching and activities of daily living. PD participants were divided into two groups, those who showed impairment in IR motor sequence production prior to training (N = 14) and those whose performance was similar to controls (N = 16). Following training the impaired PD group showed significantly greater reduction in sequence initiation and completion time and in error rate for IR conditions compared to the unimpaired PD and control groups. All groups improved on Trails B-A, and pre-training Trails B was identified as a predictor of training-based improvement in IR sequence completion time and error rate. Our findings highlight the importance of neurorehabilitation tailored to the specific cognitive deficits of the PD patient.

AB - While Parkinson's disease (PD) is considered a motor disorder, motor signs of PD can be exacerbated by cognitive dysfunction. We evaluated the efficacy of a computer-based cognitive rehabilitation training program designed to improve motor-related executive function. Thirty people with PD and 21 controls participated in the 10-day training. Training consisted of a two-phase button press task. First, subjects produced an externally cued (EC) digit sequence, typing numbers displayed on the computer screen. Second, subjects were prompted to generate the same sequence in the absence of the number display (internally represented sequence, IR). Sequence length was automatically adjusted to maintain 87% correct performance. Participants were evaluated before and after training using a fixed version of the training task, and generalization of training was assessed using measures involving IR motor sequencing, switching and activities of daily living. PD participants were divided into two groups, those who showed impairment in IR motor sequence production prior to training (N = 14) and those whose performance was similar to controls (N = 16). Following training the impaired PD group showed significantly greater reduction in sequence initiation and completion time and in error rate for IR conditions compared to the unimpaired PD and control groups. All groups improved on Trails B-A, and pre-training Trails B was identified as a predictor of training-based improvement in IR sequence completion time and error rate. Our findings highlight the importance of neurorehabilitation tailored to the specific cognitive deficits of the PD patient.

KW - Adaptive training

KW - Cognitive rehabilitation

KW - Movement initiation

KW - Parkinson's disease

KW - Sequencing

UR - http://www.scopus.com/inward/record.url?scp=84862783439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862783439&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2012.02.073

DO - 10.1016/j.brainres.2012.02.073

M3 - Article

C2 - 22459048

AN - SCOPUS:84862783439

VL - 1452

SP - 151

EP - 164

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -