Efficacy of rifabutin in the treatment of AIDS-related complex

Barbara Weiser, Harold Burger, D. J. Eilbott, K. Gehan, K. Flaherty, J. Gulla, S. Neff, B. Davidson, R. Anand, F. P. Siegal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We performed a phase 1-2 antiviral dose escalation trial of rifabutin, a rifamycin antibiotic with anti-HIV-1 activity in vitro. We followed 16 men with AIDS-related complex (ARC) for a mean duration of 29 weeks; the maximum toxicity-limited dose of rifabutin was 2400 mg/day, which was achieved in two patients. There was some evidence of anti-HIV-1 activity in two patients, one of whom had an improvement in immune status, but 11 of the 16 patients showed a deterioration in either virologic or immunologic status. The majority of the patients under study remained clinically stable during the trial, but there was clinical deterioration in the three who entered with CD4 cell counts of less than 100 x 106/l. On the basis of this trial, rifabutin as a single antiviral agent does not appear to be beneficial to ARC patients.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalAIDS
Volume3
Issue number12
StatePublished - 1989
Externally publishedYes

Keywords

  • AIDS-related complex
  • ansamycin
  • antiviral therapy
  • HIV-1
  • Rifabutin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Weiser, B., Burger, H., Eilbott, D. J., Gehan, K., Flaherty, K., Gulla, J., Neff, S., Davidson, B., Anand, R., & Siegal, F. P. (1989). Efficacy of rifabutin in the treatment of AIDS-related complex. AIDS, 3(12), 823-827.