Efficacy of photodynamic therapy vs other interventions in randomized clinical trials for the treatment of actinic keratoses a systematic review and meta-Analysis

Gayatri Patel, April W. Armstrong, Daniel B Eisen

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


OBJECTIVE: To determine the effectiveness of PDT for the treatment of AKs relative to other methods.

IMPORTANCE: Photodynamic therapy (PDT) is used extensively to treat actinic keratoses (AKs). An analysis of the effectiveness of PDT compared with other treatments may help physicians decide what role it should play in their own clinical practices.

DATA SOURCES: MEDLINE, EMBASE,Web of Knowledge, and Cochrane Central Register. No restrictions on years were placed, and all searches extended to the year of each database inception. Our search was conducted on March 20, 2013, and included the search terms solar keratosis, actinic keratosis, photodynamic therapy, and photochemotherapy. No restrictions were used for the search string.

STUDY SELECTION: Only randomized PDT trials that used aminolevulinic acid hydrochloride or methyl aminolevulinate hydrochloride as stabilizers with 10 or more participants were considered. Two of the authors undertook the search independently.

DATA EXTRACTION AND SYNTHESIS: Datawere extracted independently by the 2 authors.We assessed data quality using the Jadad scoring system and used a random-effects model for pooled data analysis.

MAIN OUTCOMES AND MEASURES: Primary outcome measures specified a prioriwere lesion response, cosmetic results, and patient satisfaction after the intervention.

RESULTS: Our search identified 875 journal articles and meeting abstracts.We excluded 862 owing to lack of adherence to our inclusion criteria or lack of author response to our queries for further information.We assessed 13 studies for inclusion in our final synthesis, of which 4 were eligible for final meta-Analysis. The only comparator for which meta-Analysis was performed was cryotherapy. Themeta-Analysis consisted of 641 participants, with a total of 2174 AKs treated with cryotherapy and 2170 AKs treated with PDT. Compared with cryotherapy, the pooled relative risk for the meta-Analysis for complete response (lesion clearance) was 1.14 (95%CI, 1.11-1.18) at 3 months after treatment. Visual inspection of a funnel plot revealed no publication bias, which was confirmed by the Begg test (P = .80).

CONCLUSIONS AND RELEVANCE: Photodynamic therapy has a 14%better chance of complete lesion clearance at 3 months after treatment than cryotherapy for thin AKs on the face and scalp.

Original languageEnglish (US)
Pages (from-to)1281-1288
Number of pages8
JournalJAMA Dermatology
Issue number12
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)


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