Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex

B. M. Shoemake, B. L. Vander Ley, B. W. Newcomer, Meera C Heller

Research output: Contribution to journalArticle

Abstract

Background: The prevention of bovine respiratory disease complex (BRD) in beef cattle is important to maintaining health and productivity of calves in feeding operations. Objective: Determine whether BRD bacterial and viral pathogens are susceptible to the lactoperoxidase/hydrogen peroxide/iodide (LPO/H2O2/I) system in vitro and to determine whether the oral administration of sodium iodide (NaI) could achieve sufficient concentrations of iodine (I) in the respiratory secretions of weaned beef calves to inactivate these pathogens in vivo. Animals: Sixteen weaned, apparently healthy, commercial beef calves from the University of Missouri, College of Veterinary Medicine teaching herd. Methods: In vitro viral and bacterial assays were performed to determine susceptibility to the LPO/H2O2/I system at varying concentrations of NaI. Sixteen randomly selected, healthy crossbred beef weanlings were administered 70 mg/kg NaI, or water, orally in a blinded, placebo-controlled trial. Blood and nasal secretions were collected for 72 hours and analyzed for I concentration. Results: Bovine herpesvirus-1, parainfluenza-3, Mannheimia haemolytica and Bibersteinia trehalosi were all inactivated or inhibited in vitro by the LPO/H2O2/I reaction. Oral administration of NaI caused a marked increase in nasal fluid I concentration with a Cmax = 181 (1,420 μM I), T12, a sufficient concentration to inactivate these pathogens in vitro. Conclusions and Clinical Importance: In vitro, the LPO/H2O2/I system inactivates and inhibits common pathogens associated with BRD. The administration of oral NaI significantly increases the I concentration of nasal fluid indicating that this system might be useful in preventing bovine respiratory infections.

Original languageEnglish (US)
Pages (from-to)516-524
Number of pages9
JournalJournal of Veterinary Internal Medicine
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Bovine Respiratory Disease Complex
Sodium Iodide
bovine respiratory disease
iodides
Nose
oral administration
Oral Administration
sodium
beef
pathogens
Mannheimia haemolytica
Bovine Herpesvirus 1
Lactoperoxidase
Paramyxoviridae Infections
Veterinary Medicine
calf feeding
secretion
calves
Respiratory Tract Infections
Iodine

Keywords

  • Bovine respiratory disease
  • cattle
  • Hypoiodous acid
  • Lactoperoxidase

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex. / Shoemake, B. M.; Vander Ley, B. L.; Newcomer, B. W.; Heller, Meera C.

In: Journal of Veterinary Internal Medicine, Vol. 32, No. 1, 01.01.2018, p. 516-524.

Research output: Contribution to journalArticle

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