Abstract
The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.
Original language | English (US) |
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Pages (from-to) | 99-107 |
Number of pages | 9 |
Journal | Journal of Medical Primatology |
Volume | 21 |
Issue number | 2-3 |
State | Published - Feb 1992 |
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)