Abstract
The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 99-107 |
| Number of pages | 9 |
| Journal | Journal of Medical Primatology |
| Volume | 21 |
| Issue number | 2-3 |
| State | Published - Feb 1992 |
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Fingerprint Dive into the research topics of 'Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.'. Together they form a unique fingerprint.
Cite this
Marthas, M., Miller, C. J., Sutjipto, S., Higgins, J., Torten, J., Lohman, B. L., Unger, R. E., Ramos, R. A., Kiyono, H., & McGhee, J. R. (1992). Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV. Journal of Medical Primatology, 21(2-3), 99-107.