Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.

Marta Marthas; Chris J Miller; S. Sutjipto; J. Higgins; J. Torten; B. L. Lohman; R. E. Unger; R. A. Ramos; H. Kiyono; J. R. McGhee

Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.

Marta Marthas, Chris J Miller, S. Sutjipto, J. Higgins, J. Torten, B. L. Lohman, R. E. Unger, R. A. Ramos, H. Kiyono, J. R. McGhee

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.

Original language	English (US)
Pages (from-to)	99-107
Number of pages	9
Journal	Journal of Medical Primatology
Volume	21
Issue number	2-3
State	Published - Feb 1992

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV. / Marthas, Marta ; Miller, Chris J; Sutjipto, S.; Higgins, J.; Torten, J.; Lohman, B. L.; Unger, R. E.; Ramos, R. A.; Kiyono, H.; McGhee, J. R.

In: Journal of Medical Primatology, Vol. 21, No. 2-3, 02.1992, p. 99-107.

Research output: Contribution to journal › Article › peer-review

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abstract = "The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.",

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AU - Higgins, J.

AU - Torten, J.

AU - Lohman, B. L.

AU - Unger, R. E.

AU - Ramos, R. A.

AU - Kiyono, H.

AU - McGhee, J. R.

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Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.

Abstract

ASJC Scopus subject areas

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