Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.

Marta Marthas, Chris J Miller, S. Sutjipto, J. Higgins, J. Torten, B. L. Lohman, R. E. Unger, R. A. Ramos, H. Kiyono, J. R. McGhee

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalJournal of Medical Primatology
Volume21
Issue number2-3
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Marthas, M., Miller, C. J., Sutjipto, S., Higgins, J., Torten, J., Lohman, B. L., Unger, R. E., Ramos, R. A., Kiyono, H., & McGhee, J. R. (1992). Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV. Journal of Medical Primatology, 21(2-3), 99-107.