Efficacy of hydrated sodium calcium aluminosilicate and activated charcoal in reducing the toxicity of dietary aflatoxin to mink

R. J. Bonna, R. J. Aulerich, S. J. Bursian, Robert H Poppenga, W. E. Braselton, G. L. Watson

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Mink were fed diets that contained 0, 34, or 102 ppb (μg/kg) aflatoxins with or without 0.5% hydrated sodium calcium aluminosilicate (HSCAS) and/or 1.0% activated charcoal (AC) for 77 days. Consumption of the diet that contained 34 ppb aflatoxins was lethal to 20% of the mink, while 102 ppb dietary aflatoxins resulted in 100% mortality within 53 days. The addition of AC to the diet containing 102 ppb aflatoxins reduced mortality and increased survival time of the mink while the addition of HSCAS, alone or in combination with AC, prevented mortality. Histologic examination of livers and kidneys from the mink demonstrated liver lesions ranging from extremely severe in mink fed 102 ppb aflatoxin to mild to moderate in those that received 34 ppb aflatoxins. The addition of HSCAS and/or AC to the diets that contained 102 ppb aflatoxins reduced or essentially eliminated histopathologic lesions in the livers. No histopathologic alterations associated with the dietary treatments were observed in the kidneys.

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalArchives of Environmental Contamination and Toxicology
Volume20
Issue number3
DOIs
StatePublished - Apr 1991
Externally publishedYes

Fingerprint

Aflatoxins
Mink
Charcoal
Aluminosilicates
aluminosilicate
charcoal
Activated carbon
Toxicity
Calcium
calcium
Sodium
sodium
diet
toxicity
Nutrition
lesion
mortality
Liver
Diet
Mortality

ASJC Scopus subject areas

  • Toxicology
  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Efficacy of hydrated sodium calcium aluminosilicate and activated charcoal in reducing the toxicity of dietary aflatoxin to mink. / Bonna, R. J.; Aulerich, R. J.; Bursian, S. J.; Poppenga, Robert H; Braselton, W. E.; Watson, G. L.

In: Archives of Environmental Contamination and Toxicology, Vol. 20, No. 3, 04.1991, p. 441-447.

Research output: Contribution to journalArticle

@article{8d7074d6f4c148b68febf4d1031f6936,
title = "Efficacy of hydrated sodium calcium aluminosilicate and activated charcoal in reducing the toxicity of dietary aflatoxin to mink",
abstract = "Mink were fed diets that contained 0, 34, or 102 ppb (μg/kg) aflatoxins with or without 0.5{\%} hydrated sodium calcium aluminosilicate (HSCAS) and/or 1.0{\%} activated charcoal (AC) for 77 days. Consumption of the diet that contained 34 ppb aflatoxins was lethal to 20{\%} of the mink, while 102 ppb dietary aflatoxins resulted in 100{\%} mortality within 53 days. The addition of AC to the diet containing 102 ppb aflatoxins reduced mortality and increased survival time of the mink while the addition of HSCAS, alone or in combination with AC, prevented mortality. Histologic examination of livers and kidneys from the mink demonstrated liver lesions ranging from extremely severe in mink fed 102 ppb aflatoxin to mild to moderate in those that received 34 ppb aflatoxins. The addition of HSCAS and/or AC to the diets that contained 102 ppb aflatoxins reduced or essentially eliminated histopathologic lesions in the livers. No histopathologic alterations associated with the dietary treatments were observed in the kidneys.",
author = "Bonna, {R. J.} and Aulerich, {R. J.} and Bursian, {S. J.} and Poppenga, {Robert H} and Braselton, {W. E.} and Watson, {G. L.}",
year = "1991",
month = "4",
doi = "10.1007/BF01064418",
language = "English (US)",
volume = "20",
pages = "441--447",
journal = "Archives of Environmental Contamination and Toxicology",
issn = "0090-4341",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Efficacy of hydrated sodium calcium aluminosilicate and activated charcoal in reducing the toxicity of dietary aflatoxin to mink

AU - Bonna, R. J.

AU - Aulerich, R. J.

AU - Bursian, S. J.

AU - Poppenga, Robert H

AU - Braselton, W. E.

AU - Watson, G. L.

PY - 1991/4

Y1 - 1991/4

N2 - Mink were fed diets that contained 0, 34, or 102 ppb (μg/kg) aflatoxins with or without 0.5% hydrated sodium calcium aluminosilicate (HSCAS) and/or 1.0% activated charcoal (AC) for 77 days. Consumption of the diet that contained 34 ppb aflatoxins was lethal to 20% of the mink, while 102 ppb dietary aflatoxins resulted in 100% mortality within 53 days. The addition of AC to the diet containing 102 ppb aflatoxins reduced mortality and increased survival time of the mink while the addition of HSCAS, alone or in combination with AC, prevented mortality. Histologic examination of livers and kidneys from the mink demonstrated liver lesions ranging from extremely severe in mink fed 102 ppb aflatoxin to mild to moderate in those that received 34 ppb aflatoxins. The addition of HSCAS and/or AC to the diets that contained 102 ppb aflatoxins reduced or essentially eliminated histopathologic lesions in the livers. No histopathologic alterations associated with the dietary treatments were observed in the kidneys.

AB - Mink were fed diets that contained 0, 34, or 102 ppb (μg/kg) aflatoxins with or without 0.5% hydrated sodium calcium aluminosilicate (HSCAS) and/or 1.0% activated charcoal (AC) for 77 days. Consumption of the diet that contained 34 ppb aflatoxins was lethal to 20% of the mink, while 102 ppb dietary aflatoxins resulted in 100% mortality within 53 days. The addition of AC to the diet containing 102 ppb aflatoxins reduced mortality and increased survival time of the mink while the addition of HSCAS, alone or in combination with AC, prevented mortality. Histologic examination of livers and kidneys from the mink demonstrated liver lesions ranging from extremely severe in mink fed 102 ppb aflatoxin to mild to moderate in those that received 34 ppb aflatoxins. The addition of HSCAS and/or AC to the diets that contained 102 ppb aflatoxins reduced or essentially eliminated histopathologic lesions in the livers. No histopathologic alterations associated with the dietary treatments were observed in the kidneys.

UR - http://www.scopus.com/inward/record.url?scp=0025845431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025845431&partnerID=8YFLogxK

U2 - 10.1007/BF01064418

DO - 10.1007/BF01064418

M3 - Article

C2 - 1650170

AN - SCOPUS:0025845431

VL - 20

SP - 441

EP - 447

JO - Archives of Environmental Contamination and Toxicology

JF - Archives of Environmental Contamination and Toxicology

SN - 0090-4341

IS - 3

ER -