The effects of β-adrenergic blockade on the efficacy of exercise training in patients with coronary artery disease were assessed in a community-based cardiac rehabilitation program. Twenty-five patients took no β-adrenergic-blocking agent and 17 patients took a constant dose of propranolol during the 3 month study period. Individual exercise prescription consisted of an intensity of 70% of maximal workload monitored by heart rate, performed 20 min each session, three sessions per week. Both groups improved in maximal exercise capacity: from 8.7 ± 1.90 (mean ± SD) to 9.7 ± 2.1 mets (p < .01) in those not taking propranolol and from 6.6 ± 1.5 to 7.7 ± 1.8 mets (p < .01) in those taking the drug. At a workload of 70% of maximal achieved at pretraining testing, heart rate decreased with training from 123 ± 19 to 113 ± 17 beats/min (p < .01) in those not taking propranolol and from 97 ± 14 to 92 ± 12 beats/min (p < .05) in those taking the drug. At a workload of 85% of pretraining maximum, heart rate similarly was lowered with training from 138 ± 17 to 126 ± 17 beats/min (p < .01) in those not taking a β-blocker and from 107 ± 13 to 102 ± 13 beats/min (p < .02) in those taking propranolol. Thus patients with coronary disease who take propranolol have the same potential to benefit from physical training as patients who do not take β-blockers, and exercise does not need to be modified because of the drug.
|Original language||English (US)|
|Number of pages||6|
|State||Published - 1983|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine