Efficacy of ceftiofur for treatment of experimental salmonellosis in neonatal calves

Maria Eve Fecteau, John K. House, Susan F. Kotarski, Natalie S. Tankersley, Monica M. Ontiveros, Carlos R. Alcantar, Bradford Smith

Research output: Contribution to journalArticle

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Abstract

Objective - To evaluate therapeutic efficacy of a high extralabel dose of ceftiofur for treatment of experimental salmonellosis in neonatal calves. Animals - Forty-two 1- to 4-day-old Holstein bull calves. Procedure - 36 calves were orally challenged with Salmonella enteritica serovar Typhimurium (6.5 × 108 colony-forming units). Six additional calves were retained as nonmedicated nonchallenged control calves. Four days following Salmonella challenge, surviving calves were randomly allocated to ceftiofurtreated (5 mg/kg, IM, q 24 h) or nonmedicated control groups. Calves assigned to the treated group were medicated daily for 5 days starting on day 4 after challenge. Calves were monitored for 18 days following Salmonella challenge. Outcome assessments included clinical parameters (attitude, appetite, fecal characteristics, and rectal temperature), mortality rate, and quantitative Salmonella culture of fecal samples, mesenteric lymph nodes, and cecal contents. Results - Ceftiofur treatment was associated with a significant decrease in rectal temperature and diarrhea. Three of 15 medicated calves and 4 of 14 nonmedicated calves died or were euthanatized between days 4 and 18. A significant decrease in fecal shedding of Salmonella organisms was observed in treated calves, compared with nonmedicated calves. Salmonella organisms were isolated from all 10 nonmedicated calves at necropsy, whereas no Salmonella organisms were isolated from 5 of 12 medicated calves. Conclusions and Clinical Relevance - Treatment of salmonellosis in neonatal calves with a high extralabel dose of ceftiofur (5 mg/kg, IM, q 24 h) promotes animal welfare, reduces fecal shedding of Salmonella organisms, and may promote clearance of Salmonella infections when plasma ceftiofur concentrations are maintained above minimal inhibitory concentrations.

Original languageEnglish (US)
Pages (from-to)918-925
Number of pages8
JournalAmerican Journal of Veterinary Research
Volume64
Issue number7
DOIs
StatePublished - Jul 1 2003

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ceftiofur
Salmonella Infections
salmonellosis
Salmonella
calves
Animal Welfare
Temperature
organisms
Appetite
Therapeutics
Diarrhea
Stem Cells
Lymph Nodes
Outcome Assessment (Health Care)
Control Groups
Mortality
appetite
dosage

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Fecteau, M. E., House, J. K., Kotarski, S. F., Tankersley, N. S., Ontiveros, M. M., Alcantar, C. R., & Smith, B. (2003). Efficacy of ceftiofur for treatment of experimental salmonellosis in neonatal calves. American Journal of Veterinary Research, 64(7), 918-925. https://doi.org/10.2460/ajvr.2003.64.918

Efficacy of ceftiofur for treatment of experimental salmonellosis in neonatal calves. / Fecteau, Maria Eve; House, John K.; Kotarski, Susan F.; Tankersley, Natalie S.; Ontiveros, Monica M.; Alcantar, Carlos R.; Smith, Bradford.

In: American Journal of Veterinary Research, Vol. 64, No. 7, 01.07.2003, p. 918-925.

Research output: Contribution to journalArticle

Fecteau, ME, House, JK, Kotarski, SF, Tankersley, NS, Ontiveros, MM, Alcantar, CR & Smith, B 2003, 'Efficacy of ceftiofur for treatment of experimental salmonellosis in neonatal calves', American Journal of Veterinary Research, vol. 64, no. 7, pp. 918-925. https://doi.org/10.2460/ajvr.2003.64.918
Fecteau ME, House JK, Kotarski SF, Tankersley NS, Ontiveros MM, Alcantar CR et al. Efficacy of ceftiofur for treatment of experimental salmonellosis in neonatal calves. American Journal of Veterinary Research. 2003 Jul 1;64(7):918-925. https://doi.org/10.2460/ajvr.2003.64.918
Fecteau, Maria Eve ; House, John K. ; Kotarski, Susan F. ; Tankersley, Natalie S. ; Ontiveros, Monica M. ; Alcantar, Carlos R. ; Smith, Bradford. / Efficacy of ceftiofur for treatment of experimental salmonellosis in neonatal calves. In: American Journal of Veterinary Research. 2003 ; Vol. 64, No. 7. pp. 918-925.
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abstract = "Objective - To evaluate therapeutic efficacy of a high extralabel dose of ceftiofur for treatment of experimental salmonellosis in neonatal calves. Animals - Forty-two 1- to 4-day-old Holstein bull calves. Procedure - 36 calves were orally challenged with Salmonella enteritica serovar Typhimurium (6.5 × 108 colony-forming units). Six additional calves were retained as nonmedicated nonchallenged control calves. Four days following Salmonella challenge, surviving calves were randomly allocated to ceftiofurtreated (5 mg/kg, IM, q 24 h) or nonmedicated control groups. Calves assigned to the treated group were medicated daily for 5 days starting on day 4 after challenge. Calves were monitored for 18 days following Salmonella challenge. Outcome assessments included clinical parameters (attitude, appetite, fecal characteristics, and rectal temperature), mortality rate, and quantitative Salmonella culture of fecal samples, mesenteric lymph nodes, and cecal contents. Results - Ceftiofur treatment was associated with a significant decrease in rectal temperature and diarrhea. Three of 15 medicated calves and 4 of 14 nonmedicated calves died or were euthanatized between days 4 and 18. A significant decrease in fecal shedding of Salmonella organisms was observed in treated calves, compared with nonmedicated calves. Salmonella organisms were isolated from all 10 nonmedicated calves at necropsy, whereas no Salmonella organisms were isolated from 5 of 12 medicated calves. Conclusions and Clinical Relevance - Treatment of salmonellosis in neonatal calves with a high extralabel dose of ceftiofur (5 mg/kg, IM, q 24 h) promotes animal welfare, reduces fecal shedding of Salmonella organisms, and may promote clearance of Salmonella infections when plasma ceftiofur concentrations are maintained above minimal inhibitory concentrations.",
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