Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets

In Jeong Kim, Paula A. Lanthier, Madeline J. Clark, Rafael A. De La Barrera, Michael P. Tighe, Frank M. Szaba, Kelsey L. Travis, Timothy C. Low-Beer, Tres S. Cookenham, Kathleen G. Lanzer, Derek T. Bernacki, Lawrence L. Johnson, Amanda A. Schneck, Corinna N. Ross, Suzette D. Tardif, Donna Layne-Colon, Stephanie D. Mdaki, Edward J. Dick, Colin Chuba, Olga GonzalezKathleen M. Brasky, John Dutton, Julienne N. Rutherford, Lark L. Coffey, Anil Singapuri, Claudia Sanchez San Martin, Charles Y. Chiu, Stephen J. Thomas, Kayvon Modjarrad, Jean L. Patterson, Marcia A. Blackman

Research output: Contribution to journalArticlepeer-review

Abstract

Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines is to prevent both maternal-fetal infection and congenital Zika syndrome. A Zika purified inactivated virus (ZPIV) was previously shown to be protective in non-pregnant mice and rhesus macaques. In this study, we further examined the efficacy of ZPIV against ZIKV infection during pregnancy in immunocompetent C57BL6 mice and common marmoset monkeys (Callithrix jacchus). We showed that, in C57BL/6 mice, ZPIV significantly reduced ZIKV-induced fetal malformations. Protection of fetuses was positively correlated with virus-neutralizing antibody levels. In marmosets, the vaccine prevented vertical transmission of ZIKV and elicited neutralizing antibodies that remained above a previously determined threshold of protection for up to 18 months. These proof-of-concept studies demonstrate ZPIV’s protective efficacy is both potent and durable and has the potential to prevent the harmful consequence of ZIKV infection during pregnancy.

Original languageEnglish (US)
Article number9
Journalnpj Vaccines
Volume7
Issue number1
DOIs
StatePublished - Dec 2022
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets'. Together they form a unique fingerprint.

Cite this