Modifications in the pulmonary vasculature of infant Macaca arctoides (stumptail monkeys) were experimentally induced by a subcutaneous injection of the pyrrolizidine alkaloid, monocrotaline. Before the monkeys died, they experienced extreme cardiopulmonary dysfunction, including altered blood pH and gases, increased packed cell volume, and greater than twofold increase in mean pulmonary arterial and right ventricular blood pressures. At necropsy, hypertrophy of the right ventricular musculature and marked dilatation of the right side of the heart were observed. Microscopically, there was endocardial thickening of the right ventricle due mainly to proliferation of collagen and elastic fibers beneath the endothelial surface. Cor pulmonale and endocardial fibrosis observed in these nonhuman primates were quite similar to their counterpart in man.
|Original language||English (US)|
|Number of pages||2|
|Journal||American Journal of Veterinary Research|
|State||Published - Jan 1 1973|
ASJC Scopus subject areas