Efficacy of a thiabendazole paste formulation to treat strongyle infections in horses

Alex Ardans, G. T. Walters

Research output: Contribution to journalArticle

Abstract

Modifications in the pulmonary vasculature of infant Macaca arctoides (stumptail monkeys) were experimentally induced by a subcutaneous injection of the pyrrolizidine alkaloid, monocrotaline. Before the monkeys died, they experienced extreme cardiopulmonary dysfunction, including altered blood pH and gases, increased packed cell volume, and greater than twofold increase in mean pulmonary arterial and right ventricular blood pressures. At necropsy, hypertrophy of the right ventricular musculature and marked dilatation of the right side of the heart were observed. Microscopically, there was endocardial thickening of the right ventricle due mainly to proliferation of collagen and elastic fibers beneath the endothelial surface. Cor pulmonale and endocardial fibrosis observed in these nonhuman primates were quite similar to their counterpart in man.

Original languageEnglish (US)
Pages (from-to)1599-1600
Number of pages2
JournalAmerican Journal of Veterinary Research
Volume34
Issue number12
StatePublished - Jan 1 1973

Fingerprint

Thiabendazole
thiabendazole
Strongylidae
Ointments
Horses
Haplorhini
monkeys
monocrotaline
lungs
Monocrotaline
Macaca arctoides
Pyrrolizidine Alkaloids
Right Ventricular Hypertrophy
horses
Pulmonary Heart Disease
Lung
pyrrolizidine alkaloids
blood pH
Elastic Tissue
blood gases

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Efficacy of a thiabendazole paste formulation to treat strongyle infections in horses. / Ardans, Alex; Walters, G. T.

In: American Journal of Veterinary Research, Vol. 34, No. 12, 01.01.1973, p. 1599-1600.

Research output: Contribution to journalArticle

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