Efficacy and tolerability of a novel herbal formulation for weight management

J. S. Stern, J. Peerson, A. T. Mishra, M. V. Sadasiva Rao, K. P. Rajeswari

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To evaluate the efficacy of an herbal blend. Design and Methods: A randomized, double-blind, clinical trial in 60 subjects with body mass index (BMI) between 30 and 40 kg/m2. Participants were randomized into two groups receiving either 400 mg herbal capsules or 400 mg placebo capsules twice daily. The herbal blend comprises of extracts from Sphaeranthus indicus and Garcinia mangostana. Participants received a standard diet (2,000 kcal per day) and walked 30 min 5 days per week. Results: After 8 weeks, significant net reductions in body weight (3.74 kg; P < 0.0001), BMI (1.61 kg/m2; P < 0.0001), and waist circumference (5.44 cm; P < 0.05) were observed in the herbal group compared with placebo. Additionally, a significant increase in serum adiponectin concentration was found in the herbal group versus placebo (P = 0.001). Adverse events were mild and were equally distributed between the two groups. In vitro studies in the 3T3-L1 adipocyte cell line showed that the herbal extract markedly downregulated the expression of peroxisome proliferator-activated receptor gamma, adipocyte-differentiation related protein, and cluster of differentiation 36 but increased adiponectin expression. The herbal extract also reduced the expression and the recruitment of perilipin onto the membrane of lipid droplets. Conclusion: Supplementation with the herbal blend resulted in a greater degree of weight loss than placebo over 8 weeks.

Original languageEnglish (US)
Pages (from-to)921-927
Number of pages7
JournalObesity
Volume21
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Placebos
Weights and Measures
Adiponectin
Adipocytes
Capsules
Garcinia mangostana
Body Mass Index
3T3-L1 Cells
Asteraceae
PPAR gamma
Waist Circumference
Membrane Lipids
Weight Loss
Down-Regulation
Body Weight
Clinical Trials
Diet
Cell Line
Serum
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Stern, J. S., Peerson, J., Mishra, A. T., Sadasiva Rao, M. V., & Rajeswari, K. P. (2013). Efficacy and tolerability of a novel herbal formulation for weight management. Obesity, 21(5), 921-927. https://doi.org/10.1002/oby.20211

Efficacy and tolerability of a novel herbal formulation for weight management. / Stern, J. S.; Peerson, J.; Mishra, A. T.; Sadasiva Rao, M. V.; Rajeswari, K. P.

In: Obesity, Vol. 21, No. 5, 05.2013, p. 921-927.

Research output: Contribution to journalArticle

Stern, JS, Peerson, J, Mishra, AT, Sadasiva Rao, MV & Rajeswari, KP 2013, 'Efficacy and tolerability of a novel herbal formulation for weight management', Obesity, vol. 21, no. 5, pp. 921-927. https://doi.org/10.1002/oby.20211
Stern JS, Peerson J, Mishra AT, Sadasiva Rao MV, Rajeswari KP. Efficacy and tolerability of a novel herbal formulation for weight management. Obesity. 2013 May;21(5):921-927. https://doi.org/10.1002/oby.20211
Stern, J. S. ; Peerson, J. ; Mishra, A. T. ; Sadasiva Rao, M. V. ; Rajeswari, K. P. / Efficacy and tolerability of a novel herbal formulation for weight management. In: Obesity. 2013 ; Vol. 21, No. 5. pp. 921-927.
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