Effects on Pulmonary Physiology of Reamed Femoral Intramedullary Nailing in an Open-Chest Sheep Model

Philip R Wolinsky, M. F. Sciadini, R. E. Parker, J. D. Plitman, J. R. Snapper, E. J. Rutherford, M. Schulman, K. D. Johnson

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We have recently developed an open-chest sheep model to monitor and study the effects of major orthopedic procedures on pulmonary physiology. In this pilot study, we focused on reamed intramedullary femoral nailing in animals without pulmonary injury. Details of the model are described herein. The control group consisted of sheep that underwent thoracotomy and invasive monitoring only, while the study group also underwent femoral osteotomy, reaming, and intramedullary nailing. Baseline, postthoracotomy, and postreaming/nailing values were recorded for mean pulmonary arterial pressure, central venous pressure, left arterial pressure, dynamic compliance, arterial blood gas, mixed venous O2, cardiac index, and mean arterial pressure so that hemodynamic and oxygen transport data could be calculated. Postprocedure values were recorded at hourly intervals for 4 h. A physiologically stable, reproducible model was created. No statistically significant differences were found between the control and experimental groups, indicating no adverse effect of femoral reaming/nailing. In one animal, using echocardiography, pulmonary embolization was documented while reaming and inserting the intramedullary nail. Reamed femoral intramedullary nailing is not detrimental to sheep with otherwise normal lungs. This finding suggests that femoral reaming and nailing in trauma patients without associated pulmonary injuries and otherwise normal lungs may be carried out without risk of inducing significant respiratory complications.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalJournal of Orthopaedic Trauma
Issue number2
StatePublished - 1996
Externally publishedYes


  • Fat embolization
  • Femur
  • Femur fracture
  • Intramedullary nail
  • Multiple trauma
  • Pulmonary physiology
  • Reaming
  • Sheep

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery
  • Physical Therapy, Sports Therapy and Rehabilitation


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