Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats

Sanghoon Cha; Patrick S Leung; Marie W. Taubeneck; Carl L Keen; M. Eric Gershwin; Radhey S. Gupta; Mark P. Fletcher

doi:10.1016/S0271-5317(05)80526-3

Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats

Sanghoon Cha, Patrick S Leung, Marie W. Taubeneck, Carl L Keen, M. Eric Gershwin, Radhey S. Gupta, Mark P. Fletcher

Research output: Contribution to journal › Article

Abstract

The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.

Original language	English (US)
Pages (from-to)	1077-1086
Number of pages	10
Journal	Nutrition Research
Volume	13
Issue number	9
DOIs	https://doi.org/10.1016/S0271-5317(05)80526-3
State	Published - 1993

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Keywords

Heat shock proteins, Zinc deficiency, Teratogenesis

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Cite this

Cha, S., Leung, P. S., Taubeneck, M. W., Keen, C. L., Gershwin, M. E., Gupta, R. S., & Fletcher, M. P. (1993). Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats. Nutrition Research, 13(9), 1077-1086. https://doi.org/10.1016/S0271-5317(05)80526-3

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10.1016/S0271-5317(05)80526-3