Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats

Sanghoon Cha; Patrick S Leung; Marie W. Taubeneck; Carl L Keen; M. Eric Gershwin; Radhey S. Gupta; Mark P. Fletcher

doi:10.1016/S0271-5317(05)80526-3

Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats

Sanghoon Cha, Patrick S Leung, Marie W. Taubeneck, Carl L Keen, M. Eric Gershwin, Radhey S. Gupta, Mark P. Fletcher

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.

Original language	English (US)
Pages (from-to)	1077-1086
Number of pages	10
Journal	Nutrition Research
Volume	13
Issue number	9
DOIs	https://doi.org/10.1016/S0271-5317(05)80526-3
State	Published - 1993

Keywords

Heat shock proteins, Zinc deficiency, Teratogenesis

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Access to Document

10.1016/S0271-5317(05)80526-3

Cite this

@article{fb27a581366846b4887337b9a254bcf6,

title = "Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats",

abstract = "The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.",

keywords = "Heat shock proteins, Zinc deficiency, Teratogenesis",

author = "Sanghoon Cha and Leung, {Patrick S} and Taubeneck, {Marie W.} and Keen, {Carl L} and Gershwin, {M. Eric} and Gupta, {Radhey S.} and Fletcher, {Mark P.}",

year = "1993",

doi = "10.1016/S0271-5317(05)80526-3",

language = "English (US)",

volume = "13",

pages = "1077--1086",

journal = "Nutrition Research",

issn = "0271-5317",

publisher = "Elsevier Inc.",

number = "9",

}

TY - JOUR

T1 - Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats

AU - Cha, Sanghoon

AU - Leung, Patrick S

AU - Taubeneck, Marie W.

AU - Keen, Carl L

AU - Gershwin, M. Eric

AU - Gupta, Radhey S.

AU - Fletcher, Mark P.

PY - 1993

Y1 - 1993

N2 - The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.

AB - The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.

KW - Heat shock proteins, Zinc deficiency, Teratogenesis

UR - http://www.scopus.com/inward/record.url?scp=0027208242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027208242&partnerID=8YFLogxK

U2 - 10.1016/S0271-5317(05)80526-3

DO - 10.1016/S0271-5317(05)80526-3

M3 - Article

AN - SCOPUS:0027208242

VL - 13

SP - 1077

EP - 1086

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 9

ER -

Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this