Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats

Sanghoon Cha, Patrick S Leung, Marie W. Taubeneck, Carl L Keen, M. Eric Gershwin, Radhey S. Gupta, Mark P. Fletcher

Research output: Contribution to journalArticle

Abstract

The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.

Original languageEnglish (US)
Pages (from-to)1077-1086
Number of pages10
JournalNutrition Research
Volume13
Issue number9
DOIs
StatePublished - 1993

Keywords

  • Heat shock proteins, Zinc deficiency, Teratogenesis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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