Abstract
The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.
Original language | English (US) |
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Pages (from-to) | 1077-1086 |
Number of pages | 10 |
Journal | Nutrition Research |
Volume | 13 |
Issue number | 9 |
DOIs | |
State | Published - 1993 |
Keywords
- Heat shock proteins, Zinc deficiency, Teratogenesis
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics