Abstract
The transcriptional expression of hsp-65 and hsp-70 in the livers of zinc (Zn)-deficient pregnant rats and their fetuses was examined. Despite the induction of severe fetal pathologies, there were no significant differences in either maternal or fetal hsp-65 or hsp-70 expression between Zn-adequate and Zn-deficient groups, although hsp-65 and hsp-70 expression varied in both groups with time of gestation. Thus, while hsp-70 mRNA content is modulated during differentiation and development, the expression of hsp-65 and hsp-70 is not influenced by Zn deprivation, even when it is extensive enough to induce fetal pathology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1077-1086 |
| Number of pages | 10 |
| Journal | Nutrition Research |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1993 |
Keywords
- Heat shock proteins, Zinc deficiency, Teratogenesis
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
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Cite this
Cha, S., Leung, P. S., Taubeneck, M. W., Keen, C. L., Gershwin, M. E., Gupta, R. S., & Fletcher, M. P. (1993). Effects of zinc deprivation on heat shock protein (hsp)-65 and-70 gene expression in pregnant rats. Nutrition Research, 13(9), 1077-1086. https://doi.org/10.1016/S0271-5317(05)80526-3