Effects of X irradiation on the growth of normal and hyperplastic mouse mammary gland transplants

L. J. Faulkin, D. J. Mitchell, Robert Cardiff, L. S. Rosenblatt, M. Goldman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To avoid the problems associated with whole-body radiation, pieces of X-irradiated normal or hyperplastic mammary tissue were transplanted to the host gland-free fat pad of nonexposed mice. The percentage of the fat pad filled by growth of the transplants at 4, 8 and 12 weeks after transplantation was measured. Growth of lobule transplants was moderately inhibited by 4 Gy. While some of the lobules survived 12 Gy, their growth was severely inhibited. The hyperplastic outgrowth lines were variable but more resistant than lobules to growth retardation. Line Z5D was more susceptible than D1, and Z5C1 was least susceptible, with 88% growing well after 12 Gy. In order to distinguish between transient and permanent growth retardation, tissue was taken from the irradiated and control transplants and retransplanted to new hosts wihtout further radiation. The second generation of X-ray-exposed tissue filled more of the fat pad than the first-generation transplants, but significantly less than the nonexposed controls. The experiments described provide a means of demonstrating X-ray-induced changes in the mammary gland from growth inhibition to carcinogenesis.

Original languageEnglish (US)
Pages (from-to)390-403
Number of pages14
JournalUnknown Journal
Volume94
Issue number2
DOIs
StatePublished - Jan 1 1983

Fingerprint

mammary glands
Human Mammary Glands
mice
Transplants
irradiation
fats
Growth
Adipose Tissue
X-Rays
transplantation
glands
Whole-Body Irradiation
radiation
Carcinogenesis
Breast
x rays
Transplantation
Radiation

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Effects of X irradiation on the growth of normal and hyperplastic mouse mammary gland transplants. / Faulkin, L. J.; Mitchell, D. J.; Cardiff, Robert; Rosenblatt, L. S.; Goldman, M.

In: Unknown Journal, Vol. 94, No. 2, 01.01.1983, p. 390-403.

Research output: Contribution to journalArticle

Faulkin, L. J. ; Mitchell, D. J. ; Cardiff, Robert ; Rosenblatt, L. S. ; Goldman, M. / Effects of X irradiation on the growth of normal and hyperplastic mouse mammary gland transplants. In: Unknown Journal. 1983 ; Vol. 94, No. 2. pp. 390-403.
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