Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia

Rogelio U. Almario, Veraphon Vonghavaravat, Rodney Wong, Siddika E Karakas

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Background: Epidemiologic studies show an inverse relation between nut consumption and coronary heart disease. Objective: We determined the effects of walnut intake on plasma fatty acids, lipoproteins, and lipoprotein subclasses in patients with combined hyperlipidemia. Design: Participants sequentially adhered to the following diets: 1) a habitual diet (HD), 2) a habitual diet plus walnuts (HD+W), 3) a low-fat diet (LFD), and 4) a low-fat diet plus walnuts (LFD+W). Results: In 13 postmenopausal women and 5 men (x̄ ± SD age 60 ± 8 y), walnut supplementation did not increase body weight despite increased energy intake and the LFD caused weight loss (1.3 ± 0.5 kg; P < 0.01). When comparing the HD with the HD+W, linoleic acid concentrations increased from 29.94 ± 1.14% to 36.85 ± 1.13% and α-linolenic acid concentrations increased from 0.78 ± 0.04% to 1.56 ± 0.11%. During the LFD+W, plasma total cholesterol concentrations decreased by 0.58 ± 0.16 mmol/L when compared with the HD and by 0.46 ± 0.14 mmol/L when compared with the LFD. LDL-cholesterol concentrations decreased by 0.46 ± 0.15 mmol/L when compared with the LFD. Measurements of lipoprotein subclasses and particle size suggested that walnut supplementation lowered cholesterol preferentially in small LDL (46.1 ± 1.9% compared with 33.4 ± 4.3%, HD compared with HD+W, respectively; P < 0.01). HDL-cholesterol concentrations decreased from 1.27 ± 0.07 mmol/L during the HD to 1.14 ± 0.07 mmol/L during the HD+W and to 1.11 ± 0.08 mmol/L during the LFD. The decrease was seen primarily in the large HDL particles. Conclusions: Walnut supplementation may beneficially alter lipid distribution among various lipoprotein subclasses even when total plasma lipids do not change. This may be an additional mechanism underlying the antiatherogenic properties of nut intake.

Original languageEnglish (US)
Pages (from-to)72-79
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume74
Issue number1
StatePublished - 2001

Fingerprint

Juglans
walnuts
hyperlipidemia
Hyperlipidemias
lipoproteins
Lipoproteins
Fat-Restricted Diet
low fat diet
Fatty Acids
Diet
fatty acids
diet
Nuts
nuts
Cholesterol
cholesterol
Lipids
alpha-Linolenic Acid
Linoleic Acid
Energy Intake

Keywords

  • Cholesterol
  • Combined hyperlipidemia
  • Coronary heart disease
  • Habitual diet
  • Lipoprotein
  • Low-fat diet
  • Plasma fatty acid
  • Walnuts

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. / Almario, Rogelio U.; Vonghavaravat, Veraphon; Wong, Rodney; Karakas, Siddika E.

In: American Journal of Clinical Nutrition, Vol. 74, No. 1, 2001, p. 72-79.

Research output: Contribution to journalArticle

Almario, Rogelio U. ; Vonghavaravat, Veraphon ; Wong, Rodney ; Karakas, Siddika E. / Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. In: American Journal of Clinical Nutrition. 2001 ; Vol. 74, No. 1. pp. 72-79.
@article{35b20446c4334b57b48eeb7d59bec4d9,
title = "Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia",
abstract = "Background: Epidemiologic studies show an inverse relation between nut consumption and coronary heart disease. Objective: We determined the effects of walnut intake on plasma fatty acids, lipoproteins, and lipoprotein subclasses in patients with combined hyperlipidemia. Design: Participants sequentially adhered to the following diets: 1) a habitual diet (HD), 2) a habitual diet plus walnuts (HD+W), 3) a low-fat diet (LFD), and 4) a low-fat diet plus walnuts (LFD+W). Results: In 13 postmenopausal women and 5 men (x̄ ± SD age 60 ± 8 y), walnut supplementation did not increase body weight despite increased energy intake and the LFD caused weight loss (1.3 ± 0.5 kg; P < 0.01). When comparing the HD with the HD+W, linoleic acid concentrations increased from 29.94 ± 1.14{\%} to 36.85 ± 1.13{\%} and α-linolenic acid concentrations increased from 0.78 ± 0.04{\%} to 1.56 ± 0.11{\%}. During the LFD+W, plasma total cholesterol concentrations decreased by 0.58 ± 0.16 mmol/L when compared with the HD and by 0.46 ± 0.14 mmol/L when compared with the LFD. LDL-cholesterol concentrations decreased by 0.46 ± 0.15 mmol/L when compared with the LFD. Measurements of lipoprotein subclasses and particle size suggested that walnut supplementation lowered cholesterol preferentially in small LDL (46.1 ± 1.9{\%} compared with 33.4 ± 4.3{\%}, HD compared with HD+W, respectively; P < 0.01). HDL-cholesterol concentrations decreased from 1.27 ± 0.07 mmol/L during the HD to 1.14 ± 0.07 mmol/L during the HD+W and to 1.11 ± 0.08 mmol/L during the LFD. The decrease was seen primarily in the large HDL particles. Conclusions: Walnut supplementation may beneficially alter lipid distribution among various lipoprotein subclasses even when total plasma lipids do not change. This may be an additional mechanism underlying the antiatherogenic properties of nut intake.",
keywords = "Cholesterol, Combined hyperlipidemia, Coronary heart disease, Habitual diet, Lipoprotein, Low-fat diet, Plasma fatty acid, Walnuts",
author = "Almario, {Rogelio U.} and Veraphon Vonghavaravat and Rodney Wong and Karakas, {Siddika E}",
year = "2001",
language = "English (US)",
volume = "74",
pages = "72--79",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "1",

}

TY - JOUR

T1 - Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia

AU - Almario, Rogelio U.

AU - Vonghavaravat, Veraphon

AU - Wong, Rodney

AU - Karakas, Siddika E

PY - 2001

Y1 - 2001

N2 - Background: Epidemiologic studies show an inverse relation between nut consumption and coronary heart disease. Objective: We determined the effects of walnut intake on plasma fatty acids, lipoproteins, and lipoprotein subclasses in patients with combined hyperlipidemia. Design: Participants sequentially adhered to the following diets: 1) a habitual diet (HD), 2) a habitual diet plus walnuts (HD+W), 3) a low-fat diet (LFD), and 4) a low-fat diet plus walnuts (LFD+W). Results: In 13 postmenopausal women and 5 men (x̄ ± SD age 60 ± 8 y), walnut supplementation did not increase body weight despite increased energy intake and the LFD caused weight loss (1.3 ± 0.5 kg; P < 0.01). When comparing the HD with the HD+W, linoleic acid concentrations increased from 29.94 ± 1.14% to 36.85 ± 1.13% and α-linolenic acid concentrations increased from 0.78 ± 0.04% to 1.56 ± 0.11%. During the LFD+W, plasma total cholesterol concentrations decreased by 0.58 ± 0.16 mmol/L when compared with the HD and by 0.46 ± 0.14 mmol/L when compared with the LFD. LDL-cholesterol concentrations decreased by 0.46 ± 0.15 mmol/L when compared with the LFD. Measurements of lipoprotein subclasses and particle size suggested that walnut supplementation lowered cholesterol preferentially in small LDL (46.1 ± 1.9% compared with 33.4 ± 4.3%, HD compared with HD+W, respectively; P < 0.01). HDL-cholesterol concentrations decreased from 1.27 ± 0.07 mmol/L during the HD to 1.14 ± 0.07 mmol/L during the HD+W and to 1.11 ± 0.08 mmol/L during the LFD. The decrease was seen primarily in the large HDL particles. Conclusions: Walnut supplementation may beneficially alter lipid distribution among various lipoprotein subclasses even when total plasma lipids do not change. This may be an additional mechanism underlying the antiatherogenic properties of nut intake.

AB - Background: Epidemiologic studies show an inverse relation between nut consumption and coronary heart disease. Objective: We determined the effects of walnut intake on plasma fatty acids, lipoproteins, and lipoprotein subclasses in patients with combined hyperlipidemia. Design: Participants sequentially adhered to the following diets: 1) a habitual diet (HD), 2) a habitual diet plus walnuts (HD+W), 3) a low-fat diet (LFD), and 4) a low-fat diet plus walnuts (LFD+W). Results: In 13 postmenopausal women and 5 men (x̄ ± SD age 60 ± 8 y), walnut supplementation did not increase body weight despite increased energy intake and the LFD caused weight loss (1.3 ± 0.5 kg; P < 0.01). When comparing the HD with the HD+W, linoleic acid concentrations increased from 29.94 ± 1.14% to 36.85 ± 1.13% and α-linolenic acid concentrations increased from 0.78 ± 0.04% to 1.56 ± 0.11%. During the LFD+W, plasma total cholesterol concentrations decreased by 0.58 ± 0.16 mmol/L when compared with the HD and by 0.46 ± 0.14 mmol/L when compared with the LFD. LDL-cholesterol concentrations decreased by 0.46 ± 0.15 mmol/L when compared with the LFD. Measurements of lipoprotein subclasses and particle size suggested that walnut supplementation lowered cholesterol preferentially in small LDL (46.1 ± 1.9% compared with 33.4 ± 4.3%, HD compared with HD+W, respectively; P < 0.01). HDL-cholesterol concentrations decreased from 1.27 ± 0.07 mmol/L during the HD to 1.14 ± 0.07 mmol/L during the HD+W and to 1.11 ± 0.08 mmol/L during the LFD. The decrease was seen primarily in the large HDL particles. Conclusions: Walnut supplementation may beneficially alter lipid distribution among various lipoprotein subclasses even when total plasma lipids do not change. This may be an additional mechanism underlying the antiatherogenic properties of nut intake.

KW - Cholesterol

KW - Combined hyperlipidemia

KW - Coronary heart disease

KW - Habitual diet

KW - Lipoprotein

KW - Low-fat diet

KW - Plasma fatty acid

KW - Walnuts

UR - http://www.scopus.com/inward/record.url?scp=0034968762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034968762&partnerID=8YFLogxK

M3 - Article

C2 - 11451720

AN - SCOPUS:0034968762

VL - 74

SP - 72

EP - 79

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 1

ER -