Abstract
Background.: Curcuma longa (common name: turmeric) and one of its biologically active constituents, curcumin, have received increased clinical attention. Insufficient data exist on the effects of curcumin and turmeric on the gut microbiota and such studies in humans are lacking. Methods.: Turmeric tablets with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3) were provided to healthy human subjects and subsequent changes in the gut microbiota were determined by 16S rDNA sequencing. Results.: The number of taxa detected ranged from 172 to 325 bacterial species. The placebo group displayed an overall reduction in species by 15%, whereas turmeric-treated subjects displayed a modest 7% increase in observed species posttreatment. Subjects taking curcumin displayed an average increase of 69% in detected species. The gut microbiota response to treatment was highly personalized, thus leading to responders and nonresponders displaying response concordance. These “responsive” subjects defined a signature involving uniform increases in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. Common to these subjects was the reduced relative abundance of several Blautia spp. and most Ruminococcus spp. Conclusions.: All participants’ microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects.
| Original language | English (US) |
|---|---|
| Journal | Journal of Evidence-Based Integrative Medicine |
| Volume | 23 |
| DOIs | |
| State | Published - Aug 3 2018 |
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Keywords
- antioxidant
- curcumin
- gastrointestinal
- microbiota
- turmeric
ASJC Scopus subject areas
- Complementary and alternative medicine
Cite this
Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota : A Double-Blind, Randomized, Placebo-Controlled Pilot Study. / Peterson, Christine T.; Vaughn, Alexandra R.; Sharma, Vandana; Chopra, Deepak; Mills, Paul J.; Peterson, Scott N.; Sivamani, Raja K.
In: Journal of Evidence-Based Integrative Medicine, Vol. 23, 03.08.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota
T2 - A Double-Blind, Randomized, Placebo-Controlled Pilot Study
AU - Peterson, Christine T.
AU - Vaughn, Alexandra R.
AU - Sharma, Vandana
AU - Chopra, Deepak
AU - Mills, Paul J.
AU - Peterson, Scott N.
AU - Sivamani, Raja K
PY - 2018/8/3
Y1 - 2018/8/3
N2 - Background.: Curcuma longa (common name: turmeric) and one of its biologically active constituents, curcumin, have received increased clinical attention. Insufficient data exist on the effects of curcumin and turmeric on the gut microbiota and such studies in humans are lacking. Methods.: Turmeric tablets with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3) were provided to healthy human subjects and subsequent changes in the gut microbiota were determined by 16S rDNA sequencing. Results.: The number of taxa detected ranged from 172 to 325 bacterial species. The placebo group displayed an overall reduction in species by 15%, whereas turmeric-treated subjects displayed a modest 7% increase in observed species posttreatment. Subjects taking curcumin displayed an average increase of 69% in detected species. The gut microbiota response to treatment was highly personalized, thus leading to responders and nonresponders displaying response concordance. These “responsive” subjects defined a signature involving uniform increases in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. Common to these subjects was the reduced relative abundance of several Blautia spp. and most Ruminococcus spp. Conclusions.: All participants’ microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects.
AB - Background.: Curcuma longa (common name: turmeric) and one of its biologically active constituents, curcumin, have received increased clinical attention. Insufficient data exist on the effects of curcumin and turmeric on the gut microbiota and such studies in humans are lacking. Methods.: Turmeric tablets with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3) were provided to healthy human subjects and subsequent changes in the gut microbiota were determined by 16S rDNA sequencing. Results.: The number of taxa detected ranged from 172 to 325 bacterial species. The placebo group displayed an overall reduction in species by 15%, whereas turmeric-treated subjects displayed a modest 7% increase in observed species posttreatment. Subjects taking curcumin displayed an average increase of 69% in detected species. The gut microbiota response to treatment was highly personalized, thus leading to responders and nonresponders displaying response concordance. These “responsive” subjects defined a signature involving uniform increases in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. Common to these subjects was the reduced relative abundance of several Blautia spp. and most Ruminococcus spp. Conclusions.: All participants’ microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects.
KW - antioxidant
KW - curcumin
KW - gastrointestinal
KW - microbiota
KW - turmeric
UR - http://www.scopus.com/inward/record.url?scp=85054864372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054864372&partnerID=8YFLogxK
U2 - 10.1177/2515690X18790725
DO - 10.1177/2515690X18790725
M3 - Article
AN - SCOPUS:85054864372
VL - 23
JO - Journal of Evidence-Based Integrative Medicine
JF - Journal of Evidence-Based Integrative Medicine
SN - 2156-5872
ER -