Effects of triclocarban on intact immature male rat: Augmentation of androgen action

Antoni J. Duleba, Mohamed I. Ahmed, Meng Sun, Allen C Gao, Jesus Villanueva, Alan J Conley, Judith L Turgeon, Kurt Benirschke, Nancy A. Gee, Jiangang Chen, Peter G. Green, Bill L. Lasley

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Triclocarban (TCC; 3,4,4′-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on human prostate LNCaP and C4-2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplemented with TCC (0.25% in diet) for 10 days. Triclocarban induced hyperplasia of accessory sex organs in the absence of significant qualitative histological changes. Serum luteinizing hormone (LH) and testosterone were not significantly altered by TCC treatment. In prostate cancer-derived LNCaP and C4-2B cells, TCC potentiated androgen actions via androgen receptor-dependent actions. In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalReproductive Sciences
Volume18
Issue number2
DOIs
StatePublished - Feb 2011

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Keywords

  • Androgen receptor
  • Endocrine-disrupting substance
  • Luteinizing hormone
  • Testosterone
  • Triclocarban

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Duleba, A. J., Ahmed, M. I., Sun, M., Gao, A. C., Villanueva, J., Conley, A. J., Turgeon, J. L., Benirschke, K., Gee, N. A., Chen, J., Green, P. G., & Lasley, B. L. (2011). Effects of triclocarban on intact immature male rat: Augmentation of androgen action. Reproductive Sciences, 18(2), 119-127. https://doi.org/10.1177/1933719110382581