Effects of time and duration of exposure to 12%O2 and prior food deprivation on hypoxic hypophagia of rats

D. D. Schnakenberg, Quinton Rogers

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A low cost, gas-dilution type, high-altitude simulator was developed and found to be a useful model for studying the effect of acute hypoxic exposure on food consumption in the rat. A distinct advantage of this system is that it provides access to the animals without disturbance to the gaseous atmosphere. The onset of hypoxic hypophagia was shown to occur within the firt 3 h following abrupt ascent to a simulated altitude of 4419.6 m (14,500 ft). The magnitude of the anorexic effect was uniform throughout the first day of exposure to 12% O2; likewise, food consumption rapidly recovered following return to a sea level atmosphere. It was concluded that the hypophagic effect of hypoxia is not absolute and that the severity of the hypophagia can be reduced by prior food deprivation. However, the degree of attenuation of the hypophagic response was not directly related to the length of the deprivation period. Food deprivation may sufficiently enhance metabolic-induced food demand signals to partially override the inhibitory effect of hypoxia on feeding behavior. Alternatively, metabolic perturbations associated with the food-deprived state may, in some undefined manner, minimize the severity of acute hypoxic stress.

Original languageEnglish (US)
Pages (from-to)1202-1206
Number of pages5
JournalAviation Space and Environmental Medicine
Volume53
Issue number12
StatePublished - Dec 1 1982

Fingerprint

Food Deprivation
Rats
Food
Atmosphere
Feeding Behavior
Oceans and Seas
Gases
Sea level
Costs and Cost Analysis
Dilution
Animals
Simulators
Hypoxia
Costs

ASJC Scopus subject areas

  • Pollution
  • Medicine(all)
  • Public Health, Environmental and Occupational Health

Cite this

Effects of time and duration of exposure to 12%O2 and prior food deprivation on hypoxic hypophagia of rats. / Schnakenberg, D. D.; Rogers, Quinton.

In: Aviation Space and Environmental Medicine, Vol. 53, No. 12, 01.12.1982, p. 1202-1206.

Research output: Contribution to journalArticle

@article{bbf920e77ce84262b864ddd260970227,
title = "Effects of time and duration of exposure to 12{\%}O2 and prior food deprivation on hypoxic hypophagia of rats",
abstract = "A low cost, gas-dilution type, high-altitude simulator was developed and found to be a useful model for studying the effect of acute hypoxic exposure on food consumption in the rat. A distinct advantage of this system is that it provides access to the animals without disturbance to the gaseous atmosphere. The onset of hypoxic hypophagia was shown to occur within the firt 3 h following abrupt ascent to a simulated altitude of 4419.6 m (14,500 ft). The magnitude of the anorexic effect was uniform throughout the first day of exposure to 12{\%} O2; likewise, food consumption rapidly recovered following return to a sea level atmosphere. It was concluded that the hypophagic effect of hypoxia is not absolute and that the severity of the hypophagia can be reduced by prior food deprivation. However, the degree of attenuation of the hypophagic response was not directly related to the length of the deprivation period. Food deprivation may sufficiently enhance metabolic-induced food demand signals to partially override the inhibitory effect of hypoxia on feeding behavior. Alternatively, metabolic perturbations associated with the food-deprived state may, in some undefined manner, minimize the severity of acute hypoxic stress.",
author = "Schnakenberg, {D. D.} and Quinton Rogers",
year = "1982",
month = "12",
day = "1",
language = "English (US)",
volume = "53",
pages = "1202--1206",
journal = "Aerospace medicine and human performance",
issn = "2375-6314",
publisher = "Aerospace Medical Association",
number = "12",

}

TY - JOUR

T1 - Effects of time and duration of exposure to 12%O2 and prior food deprivation on hypoxic hypophagia of rats

AU - Schnakenberg, D. D.

AU - Rogers, Quinton

PY - 1982/12/1

Y1 - 1982/12/1

N2 - A low cost, gas-dilution type, high-altitude simulator was developed and found to be a useful model for studying the effect of acute hypoxic exposure on food consumption in the rat. A distinct advantage of this system is that it provides access to the animals without disturbance to the gaseous atmosphere. The onset of hypoxic hypophagia was shown to occur within the firt 3 h following abrupt ascent to a simulated altitude of 4419.6 m (14,500 ft). The magnitude of the anorexic effect was uniform throughout the first day of exposure to 12% O2; likewise, food consumption rapidly recovered following return to a sea level atmosphere. It was concluded that the hypophagic effect of hypoxia is not absolute and that the severity of the hypophagia can be reduced by prior food deprivation. However, the degree of attenuation of the hypophagic response was not directly related to the length of the deprivation period. Food deprivation may sufficiently enhance metabolic-induced food demand signals to partially override the inhibitory effect of hypoxia on feeding behavior. Alternatively, metabolic perturbations associated with the food-deprived state may, in some undefined manner, minimize the severity of acute hypoxic stress.

AB - A low cost, gas-dilution type, high-altitude simulator was developed and found to be a useful model for studying the effect of acute hypoxic exposure on food consumption in the rat. A distinct advantage of this system is that it provides access to the animals without disturbance to the gaseous atmosphere. The onset of hypoxic hypophagia was shown to occur within the firt 3 h following abrupt ascent to a simulated altitude of 4419.6 m (14,500 ft). The magnitude of the anorexic effect was uniform throughout the first day of exposure to 12% O2; likewise, food consumption rapidly recovered following return to a sea level atmosphere. It was concluded that the hypophagic effect of hypoxia is not absolute and that the severity of the hypophagia can be reduced by prior food deprivation. However, the degree of attenuation of the hypophagic response was not directly related to the length of the deprivation period. Food deprivation may sufficiently enhance metabolic-induced food demand signals to partially override the inhibitory effect of hypoxia on feeding behavior. Alternatively, metabolic perturbations associated with the food-deprived state may, in some undefined manner, minimize the severity of acute hypoxic stress.

UR - http://www.scopus.com/inward/record.url?scp=0020441481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020441481&partnerID=8YFLogxK

M3 - Article

C2 - 7159341

AN - SCOPUS:0020441481

VL - 53

SP - 1202

EP - 1206

JO - Aerospace medicine and human performance

JF - Aerospace medicine and human performance

SN - 2375-6314

IS - 12

ER -