Abstract
Intraperitoneal (i.p.) injections of toxic amounts of thiourea result in pulmonary edema and pleural effusions. Following i.p. injections of sublethal doses a predominance of pleural effusion over pulmonary edema is demonstrated. Pleural effusion resulting from a sublethal dose of thiourea was seen at 6 h, reached a maximum at 12 h, remained constant until 24 h, and disappeared entirely by 48 h. Administration of 2 doses of Actinomycin D (Act D) (100 μg/kg i.p. 12 h apart) was found to produce profuse pleural and peritoneal effusions without causing pulmonary edema. This was in distinct contrast to intratracheal instillation (50 μg/kg 24 h apart) which produced a large amount of pulmonary edema and little pleural effusion. In general, the effects of thiourea in rats pretreated with Act D i.p. were the development of a greater degree of pleural effusion and a lesser degree of pulmonary edema. In addition, a dose-related reduction in the formation of peritoneal effusion was noticed in these rats. Rats pretreated i.p. with Act D were 4 times more sensitive to the lethal effect of thiourea than controls. It is postulated that Act D pretreatment somehow increases capillary permeability which enhances thiourea toxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-222 |
| Number of pages | 12 |
| Journal | Toxicology |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
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- Toxicology
Cite this
Effects of thiourea on pulmonary edema, pleural and peritoneal effusions and toxicity in rats pretreated with actinomycin D. / Giri, S. N.; Hollinger, M. A.; Cross, Carroll E; Dungworth, D. L.
In: Toxicology, Vol. 2, No. 3, 1974, p. 211-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of thiourea on pulmonary edema, pleural and peritoneal effusions and toxicity in rats pretreated with actinomycin D
AU - Giri, S. N.
AU - Hollinger, M. A.
AU - Cross, Carroll E
AU - Dungworth, D. L.
PY - 1974
Y1 - 1974
N2 - Intraperitoneal (i.p.) injections of toxic amounts of thiourea result in pulmonary edema and pleural effusions. Following i.p. injections of sublethal doses a predominance of pleural effusion over pulmonary edema is demonstrated. Pleural effusion resulting from a sublethal dose of thiourea was seen at 6 h, reached a maximum at 12 h, remained constant until 24 h, and disappeared entirely by 48 h. Administration of 2 doses of Actinomycin D (Act D) (100 μg/kg i.p. 12 h apart) was found to produce profuse pleural and peritoneal effusions without causing pulmonary edema. This was in distinct contrast to intratracheal instillation (50 μg/kg 24 h apart) which produced a large amount of pulmonary edema and little pleural effusion. In general, the effects of thiourea in rats pretreated with Act D i.p. were the development of a greater degree of pleural effusion and a lesser degree of pulmonary edema. In addition, a dose-related reduction in the formation of peritoneal effusion was noticed in these rats. Rats pretreated i.p. with Act D were 4 times more sensitive to the lethal effect of thiourea than controls. It is postulated that Act D pretreatment somehow increases capillary permeability which enhances thiourea toxicity.
AB - Intraperitoneal (i.p.) injections of toxic amounts of thiourea result in pulmonary edema and pleural effusions. Following i.p. injections of sublethal doses a predominance of pleural effusion over pulmonary edema is demonstrated. Pleural effusion resulting from a sublethal dose of thiourea was seen at 6 h, reached a maximum at 12 h, remained constant until 24 h, and disappeared entirely by 48 h. Administration of 2 doses of Actinomycin D (Act D) (100 μg/kg i.p. 12 h apart) was found to produce profuse pleural and peritoneal effusions without causing pulmonary edema. This was in distinct contrast to intratracheal instillation (50 μg/kg 24 h apart) which produced a large amount of pulmonary edema and little pleural effusion. In general, the effects of thiourea in rats pretreated with Act D i.p. were the development of a greater degree of pleural effusion and a lesser degree of pulmonary edema. In addition, a dose-related reduction in the formation of peritoneal effusion was noticed in these rats. Rats pretreated i.p. with Act D were 4 times more sensitive to the lethal effect of thiourea than controls. It is postulated that Act D pretreatment somehow increases capillary permeability which enhances thiourea toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0016229750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016229750&partnerID=8YFLogxK
U2 - 10.1016/0300-483X(74)90012-2
DO - 10.1016/0300-483X(74)90012-2
M3 - Article
C2 - 4851782
AN - SCOPUS:0016229750
VL - 2
SP - 211
EP - 222
JO - Toxicology
JF - Toxicology
SN - 0300-483X
IS - 3
ER -