Effects of theophylline on behavioral state development in the newborn rabbit

V. H. Denenberg, L. P. Zeidner, E. B. Thoman, P. Kramer, J. C. Rowe, Anthony F Philipps, J. R. Raye

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18 Scopus citations


On Day 1 of life (Day O = birth), the sleep-wake behavioral states of rabbits were measured for 2 hr, after which half the animals received 10 mg/kg of theophylline by intubation (N = 16), whereas the remainder received normal saline (N = 17). Behavioural states were then measured on Days 2, 3, 5, 7, 15, 20, 30, and 40. Theophylline sharply reduced active sleep starting on Day 2 and continuing through Day 20. The development of quiet sleep was delayed for 10 days in the drug-treated group. Paralleling the loss of active sleep was a major increase in wake between Days 2 to 20. The drug also affected the intermediate states of sleep-wake transition and active-quiet sleep transition. The data raise major questions about the safety of a drug widely used in the newborn intensive care setting.

Original languageEnglish (US)
Pages (from-to)604-608
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Issue number3
StatePublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Pharmacology

Cite this

Denenberg, V. H., Zeidner, L. P., Thoman, E. B., Kramer, P., Rowe, J. C., Philipps, A. F., & Raye, J. R. (1982). Effects of theophylline on behavioral state development in the newborn rabbit. Journal of Pharmacology and Experimental Therapeutics, 221(3), 604-608.