Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium

Uma Shanmugasundaram, Joan F. Hilton, J. William Critchfield, Ruth M. Greenblatt, Linda C. Giudice, Sarah Averbach, Dominika Seidman, Barbara Shacklett, Karen Smith-McCune

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Problem: There is little information regarding the impact of the intrauterine device on immune parameters of the upper female reproductive tract related to risk of HIV acquisition. Method of Study: We collected cervical and endometrial samples from women using the hormonal intrauterine device to study its effects on endocervical cytokines/chemokine concentrations, phenotypic markers of T cells, responses of endometrial T cells to activation, and alterations of endometrial cellular infiltrates. Results: Hormonal intrauterine device use was associated with: increased concentrations of inflammatory cytokines/chemokines (endocervix); increased coexpression of CXCR4 and CCR5 (endocervix and endometrium); increased coexpression of CD38 and HLADR (endocervix and endometrium); increased intracellular IL-10 production after T-cell stimulation (endometrium); and increased density of T cells, most notably regulatory T cells (endometrium). Conclusion: Hormonal intrauterine device use resulted in both inflammatory and immunosuppressive alterations. Further research is needed to determine the significance of these changes for HIV risk.

Original languageEnglish (US)
Pages (from-to)137-148
Number of pages12
JournalAmerican Journal of Reproductive Immunology
Volume76
Issue number2
DOIs
StatePublished - Aug 1 2016

Keywords

  • chemokine
  • cytokine
  • HIV
  • IUD
  • progestin
  • T-cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium'. Together they form a unique fingerprint.

  • Cite this

    Shanmugasundaram, U., Hilton, J. F., Critchfield, J. W., Greenblatt, R. M., Giudice, L. C., Averbach, S., Seidman, D., Shacklett, B., & Smith-McCune, K. (2016). Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium. American Journal of Reproductive Immunology, 76(2), 137-148. https://doi.org/10.1111/aji.12535