TY - JOUR
T1 - Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters
AU - Farrokhi, Catherine
AU - Blanchard, D. Caroline
AU - Griebel, Guy
AU - Yang, Mu
AU - Gonzales, Coty
AU - Markham, Chris
AU - Blanchard, Robert J.
PY - 2004/3
Y1 - 2004/3
N2 - Corticotropin-releasing factor (CRF) and its receptor subtypes have been implicated in endocrine and behavioral responsivity to stress and emotion, including fear, anxiety, and aggression. SSR125543A is a new nonpeptide selective antagonist at the CRF1 receptor that has been shown to produce an anxiolytic-like effect in a number of animal models of anxiety. The present study investigated effects of an oral dose of 10, or 30 mg/kg of SSR125543A on aggressive behaviors of resident male Syrian hamsters toward male intruders. The high dose (30 mg/kg) of the CRF1 receptor antagonist produced a higher latency to bite and lower lateral attack frequencies and chase durations, indicating a reduction in aggression toward intruders in resident hamsters. The same dose of SSR125543A also enhanced frequency and duration of olfactory investigation, indicating that neither avoidance of the opponent nor deficiency in social activity is responsible for the reduction in aggression seen in these animals.
AB - Corticotropin-releasing factor (CRF) and its receptor subtypes have been implicated in endocrine and behavioral responsivity to stress and emotion, including fear, anxiety, and aggression. SSR125543A is a new nonpeptide selective antagonist at the CRF1 receptor that has been shown to produce an anxiolytic-like effect in a number of animal models of anxiety. The present study investigated effects of an oral dose of 10, or 30 mg/kg of SSR125543A on aggressive behaviors of resident male Syrian hamsters toward male intruders. The high dose (30 mg/kg) of the CRF1 receptor antagonist produced a higher latency to bite and lower lateral attack frequencies and chase durations, indicating a reduction in aggression toward intruders in resident hamsters. The same dose of SSR125543A also enhanced frequency and duration of olfactory investigation, indicating that neither avoidance of the opponent nor deficiency in social activity is responsible for the reduction in aggression seen in these animals.
KW - Agression
KW - Anxiolytic-like effect
KW - Corticotropin-releasing factor
UR - http://www.scopus.com/inward/record.url?scp=1542270300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542270300&partnerID=8YFLogxK
U2 - 10.1016/j.pbb.2003.12.023
DO - 10.1016/j.pbb.2003.12.023
M3 - Article
C2 - 15006456
AN - SCOPUS:1542270300
VL - 77
SP - 465
EP - 469
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 3
ER -