Effects of testosterone propionate and dihydrotestosterone on penile morphology and sexual reflexes of spinal male rats

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Abstract

Testosterone propionate (TP) has a quantitative influence on sexual reflexes mediated at the spinal level in male rats. The possibility that this influence reflects the direct action of androgen on neural elements in the cord, rather than on sensory receptors in the penis was examined indirectly by the use of dihydrotestosterone (DHT). Spinal castrated male rats maintained initially on TP and then switched to DHT showed a significant decline in sexual reflexes paralleling the decline of another group of spinal rats receiving no hormone after initial TP treatment. Yet the number of penile papillae and weight of the penile shaft for the DHT subjects were not significantly different from these measures of penile morphology in a third group of subjects receiving continuous TP and in which reflexes did not decline. These and other observations are consistent with the hypothesis that neural elements within the spinal cord, related to the mediation of the ejaculatory pattern in intact male rats, are indirectly influenced by gonadal androgen.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalHormones and Behavior
Volume5
Issue number3
StatePublished - Jan 1 1974

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Testosterone Propionate
Dihydrotestosterone
Reflex
Androgens
Penis
Sensory Receptor Cells
Spinal Cord
Hormones
Weights and Measures
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

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abstract = "Testosterone propionate (TP) has a quantitative influence on sexual reflexes mediated at the spinal level in male rats. The possibility that this influence reflects the direct action of androgen on neural elements in the cord, rather than on sensory receptors in the penis was examined indirectly by the use of dihydrotestosterone (DHT). Spinal castrated male rats maintained initially on TP and then switched to DHT showed a significant decline in sexual reflexes paralleling the decline of another group of spinal rats receiving no hormone after initial TP treatment. Yet the number of penile papillae and weight of the penile shaft for the DHT subjects were not significantly different from these measures of penile morphology in a third group of subjects receiving continuous TP and in which reflexes did not decline. These and other observations are consistent with the hypothesis that neural elements within the spinal cord, related to the mediation of the ejaculatory pattern in intact male rats, are indirectly influenced by gonadal androgen.",
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