Effects of synthetic micro- and nano-structured surfaces on cell behavior

R. G. Flemming, Christopher J Murphy, G. A. Abrams, S. L. Goodman, P. F. Nealey

Research output: Contribution to journalArticle

1170 Citations (Scopus)

Abstract

Topographical cues, independent of biochemistry, generated by the extracellular matrix may have significant effects upon cellular behavior. Studies have documented that substratum topography has direct effects on the ability of cells to orient themselves, migrate, and produce organized cytoskeletal arrangements. Basement membranes are composed of extracellular matrix proteins and found throughout the vertebrate body, serving as substrata for overlying cellular structures. The topography of basement membranes is a complex meshwork of pores, fibers, ridges, and other features of nanometer sized dimensions. Synthetic surfaces with topographical features have been shown to influence cell behavior. These facts lead to the hypothesis that the topography of the basement membrane plays an important role in regulating cellular behavior in a manner distinct from that of the chemistry of the basement membrane. This paper describes the topography of the basement membrane and reviews the fabrication of synthetic micro- and nano-structured surfaces and the effects of such textured surfaces on cell behavior.

Original languageEnglish (US)
Pages (from-to)573-588
Number of pages16
JournalBiomaterials
Volume20
Issue number6
DOIs
StatePublished - Mar 1999
Externally publishedYes

Fingerprint

Basement Membrane
Topography
Biochemistry
Aptitude
Extracellular Matrix Proteins
Cellular Structures
Cues
Extracellular Matrix
Vertebrates
Proteins
Fabrication
Fibers

Keywords

  • Basement membranes
  • Cell behavior

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Effects of synthetic micro- and nano-structured surfaces on cell behavior. / Flemming, R. G.; Murphy, Christopher J; Abrams, G. A.; Goodman, S. L.; Nealey, P. F.

In: Biomaterials, Vol. 20, No. 6, 03.1999, p. 573-588.

Research output: Contribution to journalArticle

Flemming, R. G. ; Murphy, Christopher J ; Abrams, G. A. ; Goodman, S. L. ; Nealey, P. F. / Effects of synthetic micro- and nano-structured surfaces on cell behavior. In: Biomaterials. 1999 ; Vol. 20, No. 6. pp. 573-588.
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