Abstract
Objective The effects of fructose and glucose consumption on plasma acylation stimulating protein (ASP), adiponectin, and leptin concentrations relative to energy intake, body weight, adiposity, circulating triglycerides, and insulin sensitivity were determined. Design and Methods Thirty two overweight/obese adults consumed glucose-or fructose-sweetened beverages (25% energy requirement) with their ad libitum diets for 8 weeks, followed by sweetened beverage consumption for 2 weeks with a standardized, energy-balanced diet. Plasma variables were measured at baseline, 2, 8, and 10 weeks, and body adiposity and insulin sensitivity at baseline and 10 weeks. Results Fasting and postprandial ASP concentrations increased at 2 and/or 8 weeks. ASP increases correlated with changes in late-evening triglyceride concentrations. At 10 weeks, fasting adiponectin levels decreased in both groups, and decreases were inversely associated with baseline intra-abdominal fat volume. Sugar consumption increased fasting leptin concentrations; increases were associated with body weight changes. The 24-h leptin profiles increased during glucose consumption and decreased during fructose consumption. These changes correlated with changes of 24-h insulin levels. Conclusions The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Further study is required to determine if these changes contribute to the metabolic dysfunction observed during fructose consumption.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2471-2480 |
| Number of pages | 10 |
| Journal | Obesity |
| Volume | 21 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2013 |
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ASJC Scopus subject areas
- Endocrinology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin : Relationships with Metabolic Outcomes. / Rezvani, Reza; Cianflone, Katherine; McGahan, John P; Berglund, Lars; Bremer, Andrew A.; Keim, Nancy L.; Griffen, Steven C.; Havel, Peter J; Stanhope, Kimber.
In: Obesity, Vol. 21, No. 12, 12.2013, p. 2471-2480.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin
T2 - Relationships with Metabolic Outcomes
AU - Rezvani, Reza
AU - Cianflone, Katherine
AU - McGahan, John P
AU - Berglund, Lars
AU - Bremer, Andrew A.
AU - Keim, Nancy L.
AU - Griffen, Steven C.
AU - Havel, Peter J
AU - Stanhope, Kimber
PY - 2013/12
Y1 - 2013/12
N2 - Objective The effects of fructose and glucose consumption on plasma acylation stimulating protein (ASP), adiponectin, and leptin concentrations relative to energy intake, body weight, adiposity, circulating triglycerides, and insulin sensitivity were determined. Design and Methods Thirty two overweight/obese adults consumed glucose-or fructose-sweetened beverages (25% energy requirement) with their ad libitum diets for 8 weeks, followed by sweetened beverage consumption for 2 weeks with a standardized, energy-balanced diet. Plasma variables were measured at baseline, 2, 8, and 10 weeks, and body adiposity and insulin sensitivity at baseline and 10 weeks. Results Fasting and postprandial ASP concentrations increased at 2 and/or 8 weeks. ASP increases correlated with changes in late-evening triglyceride concentrations. At 10 weeks, fasting adiponectin levels decreased in both groups, and decreases were inversely associated with baseline intra-abdominal fat volume. Sugar consumption increased fasting leptin concentrations; increases were associated with body weight changes. The 24-h leptin profiles increased during glucose consumption and decreased during fructose consumption. These changes correlated with changes of 24-h insulin levels. Conclusions The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Further study is required to determine if these changes contribute to the metabolic dysfunction observed during fructose consumption.
AB - Objective The effects of fructose and glucose consumption on plasma acylation stimulating protein (ASP), adiponectin, and leptin concentrations relative to energy intake, body weight, adiposity, circulating triglycerides, and insulin sensitivity were determined. Design and Methods Thirty two overweight/obese adults consumed glucose-or fructose-sweetened beverages (25% energy requirement) with their ad libitum diets for 8 weeks, followed by sweetened beverage consumption for 2 weeks with a standardized, energy-balanced diet. Plasma variables were measured at baseline, 2, 8, and 10 weeks, and body adiposity and insulin sensitivity at baseline and 10 weeks. Results Fasting and postprandial ASP concentrations increased at 2 and/or 8 weeks. ASP increases correlated with changes in late-evening triglyceride concentrations. At 10 weeks, fasting adiponectin levels decreased in both groups, and decreases were inversely associated with baseline intra-abdominal fat volume. Sugar consumption increased fasting leptin concentrations; increases were associated with body weight changes. The 24-h leptin profiles increased during glucose consumption and decreased during fructose consumption. These changes correlated with changes of 24-h insulin levels. Conclusions The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Further study is required to determine if these changes contribute to the metabolic dysfunction observed during fructose consumption.
UR - http://www.scopus.com/inward/record.url?scp=84889636080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84889636080&partnerID=8YFLogxK
U2 - 10.1002/oby.20437
DO - 10.1002/oby.20437
M3 - Article
C2 - 23512943
AN - SCOPUS:84889636080
VL - 21
SP - 2471
EP - 2480
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 12
ER -