Effects of six versus three times per week hemodialysis on physical performance, health, and functioning: Frequent hemodialysis network (FHN) randomized trials

Yoshio N. Hall, Brett Larive, Patricia Painter, George Kaysen, Robert M. Lindsay, Allen R. Nissenson, Mark L. Unruh, Michael V. Rocco, Glenn M. Chertow

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background and objectives Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. Design, setting, participants, & measurements This study examined changes in physical performance and selfreported physical health and functioning among subjects randomized to frequent (six times perweek) compared with conventional (three times per week) hemodialysis in both the Frequent Hemodialysis Network daily (n=245) and nocturnal (n=87) trials. The main outcome measures were adjusted change in scores over 12 months on the short physical performance battery (SPPB), RAND 36-item health survey physical health composite (PHC), and physical functioning subscale (PF) based on the intention to treat principle. Results Overall scores for SPPB, PHC, and PF were poor relative to population norms and in line with other studies in ESRD. In the Daily Trial, subjects randomized to frequent compared with conventional in-center hemodialysis experienced no significant change in SPPB (adjusted mean change of 20.2060.19 versus 20.4160.21, P=0.45) but experienced significant improvement in PHC (3.460.8 versus 0.460.8, P=0.009) and a relatively large change in PF that did not reach statistical significance. In the Nocturnal Trial, there were no significant differences among subjects randomized to frequent compared with conventional hemodialysis in SPPB (adjusted mean change of 20.9260.44 versus 20.4160.43, P=0.41), PHC (2.761.4 versus 2.161.5, P=0.75), or PF (23.163.5 versus 1.163.6, P=0.40). Conclusions Frequent in-center hemodialysis compared with conventional in-center hemodialysis improved self-reported physical health and functioning but had no significant effect on objective physical performance. There were no significant effects of frequent nocturnal hemodialysis on the same physical metrics.

Original languageEnglish (US)
Pages (from-to)782-794
Number of pages13
JournalClinical Journal of the American Society of Nephrology
Volume7
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Renal Dialysis
Health
Chronic Kidney Failure
Health Surveys
Outcome Assessment (Health Care)
Population

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Effects of six versus three times per week hemodialysis on physical performance, health, and functioning : Frequent hemodialysis network (FHN) randomized trials. / Hall, Yoshio N.; Larive, Brett; Painter, Patricia; Kaysen, George; Lindsay, Robert M.; Nissenson, Allen R.; Unruh, Mark L.; Rocco, Michael V.; Chertow, Glenn M.

In: Clinical Journal of the American Society of Nephrology, Vol. 7, No. 5, 01.05.2012, p. 782-794.

Research output: Contribution to journalArticle

Hall, Yoshio N. ; Larive, Brett ; Painter, Patricia ; Kaysen, George ; Lindsay, Robert M. ; Nissenson, Allen R. ; Unruh, Mark L. ; Rocco, Michael V. ; Chertow, Glenn M. / Effects of six versus three times per week hemodialysis on physical performance, health, and functioning : Frequent hemodialysis network (FHN) randomized trials. In: Clinical Journal of the American Society of Nephrology. 2012 ; Vol. 7, No. 5. pp. 782-794.
@article{183f7c8c6afc4233821b260ae240456e,
title = "Effects of six versus three times per week hemodialysis on physical performance, health, and functioning: Frequent hemodialysis network (FHN) randomized trials",
abstract = "Background and objectives Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. Design, setting, participants, & measurements This study examined changes in physical performance and selfreported physical health and functioning among subjects randomized to frequent (six times perweek) compared with conventional (three times per week) hemodialysis in both the Frequent Hemodialysis Network daily (n=245) and nocturnal (n=87) trials. The main outcome measures were adjusted change in scores over 12 months on the short physical performance battery (SPPB), RAND 36-item health survey physical health composite (PHC), and physical functioning subscale (PF) based on the intention to treat principle. Results Overall scores for SPPB, PHC, and PF were poor relative to population norms and in line with other studies in ESRD. In the Daily Trial, subjects randomized to frequent compared with conventional in-center hemodialysis experienced no significant change in SPPB (adjusted mean change of 20.2060.19 versus 20.4160.21, P=0.45) but experienced significant improvement in PHC (3.460.8 versus 0.460.8, P=0.009) and a relatively large change in PF that did not reach statistical significance. In the Nocturnal Trial, there were no significant differences among subjects randomized to frequent compared with conventional hemodialysis in SPPB (adjusted mean change of 20.9260.44 versus 20.4160.43, P=0.41), PHC (2.761.4 versus 2.161.5, P=0.75), or PF (23.163.5 versus 1.163.6, P=0.40). Conclusions Frequent in-center hemodialysis compared with conventional in-center hemodialysis improved self-reported physical health and functioning but had no significant effect on objective physical performance. There were no significant effects of frequent nocturnal hemodialysis on the same physical metrics.",
author = "Hall, {Yoshio N.} and Brett Larive and Patricia Painter and George Kaysen and Lindsay, {Robert M.} and Nissenson, {Allen R.} and Unruh, {Mark L.} and Rocco, {Michael V.} and Chertow, {Glenn M.}",
year = "2012",
month = "5",
day = "1",
doi = "10.2215/CJN.10601011",
language = "English (US)",
volume = "7",
pages = "782--794",
journal = "Clinical Journal of the American Society of Nephrology",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "5",

}

TY - JOUR

T1 - Effects of six versus three times per week hemodialysis on physical performance, health, and functioning

T2 - Frequent hemodialysis network (FHN) randomized trials

AU - Hall, Yoshio N.

AU - Larive, Brett

AU - Painter, Patricia

AU - Kaysen, George

AU - Lindsay, Robert M.

AU - Nissenson, Allen R.

AU - Unruh, Mark L.

AU - Rocco, Michael V.

AU - Chertow, Glenn M.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Background and objectives Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. Design, setting, participants, & measurements This study examined changes in physical performance and selfreported physical health and functioning among subjects randomized to frequent (six times perweek) compared with conventional (three times per week) hemodialysis in both the Frequent Hemodialysis Network daily (n=245) and nocturnal (n=87) trials. The main outcome measures were adjusted change in scores over 12 months on the short physical performance battery (SPPB), RAND 36-item health survey physical health composite (PHC), and physical functioning subscale (PF) based on the intention to treat principle. Results Overall scores for SPPB, PHC, and PF were poor relative to population norms and in line with other studies in ESRD. In the Daily Trial, subjects randomized to frequent compared with conventional in-center hemodialysis experienced no significant change in SPPB (adjusted mean change of 20.2060.19 versus 20.4160.21, P=0.45) but experienced significant improvement in PHC (3.460.8 versus 0.460.8, P=0.009) and a relatively large change in PF that did not reach statistical significance. In the Nocturnal Trial, there were no significant differences among subjects randomized to frequent compared with conventional hemodialysis in SPPB (adjusted mean change of 20.9260.44 versus 20.4160.43, P=0.41), PHC (2.761.4 versus 2.161.5, P=0.75), or PF (23.163.5 versus 1.163.6, P=0.40). Conclusions Frequent in-center hemodialysis compared with conventional in-center hemodialysis improved self-reported physical health and functioning but had no significant effect on objective physical performance. There were no significant effects of frequent nocturnal hemodialysis on the same physical metrics.

AB - Background and objectives Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. Design, setting, participants, & measurements This study examined changes in physical performance and selfreported physical health and functioning among subjects randomized to frequent (six times perweek) compared with conventional (three times per week) hemodialysis in both the Frequent Hemodialysis Network daily (n=245) and nocturnal (n=87) trials. The main outcome measures were adjusted change in scores over 12 months on the short physical performance battery (SPPB), RAND 36-item health survey physical health composite (PHC), and physical functioning subscale (PF) based on the intention to treat principle. Results Overall scores for SPPB, PHC, and PF were poor relative to population norms and in line with other studies in ESRD. In the Daily Trial, subjects randomized to frequent compared with conventional in-center hemodialysis experienced no significant change in SPPB (adjusted mean change of 20.2060.19 versus 20.4160.21, P=0.45) but experienced significant improvement in PHC (3.460.8 versus 0.460.8, P=0.009) and a relatively large change in PF that did not reach statistical significance. In the Nocturnal Trial, there were no significant differences among subjects randomized to frequent compared with conventional hemodialysis in SPPB (adjusted mean change of 20.9260.44 versus 20.4160.43, P=0.41), PHC (2.761.4 versus 2.161.5, P=0.75), or PF (23.163.5 versus 1.163.6, P=0.40). Conclusions Frequent in-center hemodialysis compared with conventional in-center hemodialysis improved self-reported physical health and functioning but had no significant effect on objective physical performance. There were no significant effects of frequent nocturnal hemodialysis on the same physical metrics.

UR - http://www.scopus.com/inward/record.url?scp=84860714431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860714431&partnerID=8YFLogxK

U2 - 10.2215/CJN.10601011

DO - 10.2215/CJN.10601011

M3 - Article

C2 - 22422538

AN - SCOPUS:84860714431

VL - 7

SP - 782

EP - 794

JO - Clinical Journal of the American Society of Nephrology

JF - Clinical Journal of the American Society of Nephrology

SN - 1555-9041

IS - 5

ER -