Effects of simultaneous viewing and vaporization of plaques using the steerable, laser‐heated metal cap in the atherosclerotic monkey model

Jerold H. Theis, Garrett Lee, Ming C. Chan, Richard M. Ikeda, Marshall H. Lee, John L. Rink, Eugene Steffey, William P. Thomas, Dean T. Mason

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A steerable, fiberoptic catheter coupled to a laser light guide tipped with a metal cap was used. Four monkeys fed an atherogenic diet for 7–8 years were angiographed and were found to have extensive mural plaque in the iliac arteries. Plaque sites in these monkeys were vaporized using the laser‐heated metal cap. Energies of 1.5–9 Joules were employed. Application of the energy was tangential or perpendicular to the plaque. Lased sites were examined histologically at 24 hr or at 3 months after treatment. No effect was seen at 1.5 Joules. Three to six Joules tangentially produced a superficial lesion that extended into the tunica intima. Six Joules perpendicularly produced a burn into the tunica adventitia, with damage to the vasavasorum. Nine Joules tangentially produced a burn into the tunica media. Three months after treatment, this lased site showed no stenosis or aneurysm formation.

Original languageEnglish (US)
Pages (from-to)414-420
Number of pages7
JournalLasers in Surgery and Medicine
Volume7
Issue number5
DOIs
StatePublished - Jan 1 1987

Keywords

  • angioplasty, laser
  • fiberoptics
  • laser angioplasy

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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