Effects of Short-Term Dried Plum (Prune) Intake on Markers of Bone Resorption and Vascular Function in Healthy Postmenopausal Women: A Randomized Crossover Trial

Yousef A. Al-Dashti, Roberta R. Holt, John G. Carson, Carl L. Keen, Robert M. Hackman

Research output: Contribution to journalArticle

Abstract

Osteoporosis and cardiovascular disease are global health burdens, with postmenopausal women being at great risk. Dried plums/prunes (DPs) have been reported to provide bone health benefits in animal models, which is consistent with in vitro models. Data from human studies suggest that DP intake can enhance lipid metabolism, anti-inflammatory, and oxidant defense systems, which can impact cardiovascular health. We tested the hypothesis that short-term consumption of low and reasonable levels of DPs augments bone resorption and vascular function. Twenty-seven healthy, postmenopausal women were randomly assigned to consume six DPs (∼42 g) or two DPs (∼14 g) per day for 2 weeks, then a 2-week washout period and then crossed over. Serum C-telopeptide, beta-crosslinked (CTX) was used as a measure of bone resorption. Peripheral artery tonometry (PAT) was used to assess microvascular function. The pattern of changes in CTX in the second 2-week period (no change or decline) differed significantly from the pattern in the first 2 weeks (increases in both groups; F = 9.26, P = .006), suggesting a trend in CTX reduction (i.e., a decrease in bone resorption) in those consuming six DPs per day in the second phase. No effects on vascular function were noted. A significant interaction was observed for the augmentation index, a measure of arterial stiffness, between treatment and years after menopause (P = .045). The results suggest a potentially favorable impact of DPs on bone health when assessed with a short-term, crossover study design in postmenopausal women. Given the novel assessments used in this study, follow-up studies are warranted.

Original languageEnglish (US)
Pages (from-to)982-992
Number of pages11
JournalJournal of Medicinal Food
Volume22
Issue number10
DOIs
StatePublished - Oct 2019

Fingerprint

Bone Resorption
Cross-Over Studies
Blood Vessels
Bone and Bones
Vascular Stiffness
Manometry
Health
Insurance Benefits
Menopause
Prunus domestica
Lipid Metabolism
Oxidants
Osteoporosis
Anti-Inflammatory Agents
Cardiovascular Diseases
Animal Models
Arteries
Serum

Keywords

  • bioactive compounds
  • bone
  • cardiovascular
  • dried plums
  • menopause
  • polyphenols
  • prunes
  • vascular

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of Short-Term Dried Plum (Prune) Intake on Markers of Bone Resorption and Vascular Function in Healthy Postmenopausal Women : A Randomized Crossover Trial. / Al-Dashti, Yousef A.; Holt, Roberta R.; Carson, John G.; Keen, Carl L.; Hackman, Robert M.

In: Journal of Medicinal Food, Vol. 22, No. 10, 10.2019, p. 982-992.

Research output: Contribution to journalArticle

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