Effects of sex hormones on cardiac repolarization

Pei Chi Yang, Colleen E Clancy

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This article reviews the current findings on the topic of gender differences derived from effects of sex steroid hormones on cardiac repolarization and drug-induced torsade de pointes. Published studies have shown that sex-related differences exist in clinical cardiac electrophysiologic measurements, and that gender is an independent risk factor in vulnerability to certain types of arrhythmia. For example, women are especially susceptible to increased arrhythmia risk in response to QT-prolonging drugs. However, a number of questions remain-especially regarding the specific influence of sex steroid hormones in gender differences. Further experimental or clinical investigations are necessary to elucidate gender differences in cardiac repolarization, QT interval prolongation, and susceptibility to cardiac arrhythmias.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume56
Issue number2
DOIs
StatePublished - Aug 2010

Fingerprint

Gonadal Steroid Hormones
Cardiac Arrhythmias
Torsades de Pointes
Sex Characteristics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of sex hormones on cardiac repolarization. / Yang, Pei Chi; Clancy, Colleen E.

In: Journal of Cardiovascular Pharmacology, Vol. 56, No. 2, 08.2010, p. 123-129.

Research output: Contribution to journalArticle

@article{d54f3f8165e446eba01a63c07c05cd39,
title = "Effects of sex hormones on cardiac repolarization",
abstract = "This article reviews the current findings on the topic of gender differences derived from effects of sex steroid hormones on cardiac repolarization and drug-induced torsade de pointes. Published studies have shown that sex-related differences exist in clinical cardiac electrophysiologic measurements, and that gender is an independent risk factor in vulnerability to certain types of arrhythmia. For example, women are especially susceptible to increased arrhythmia risk in response to QT-prolonging drugs. However, a number of questions remain-especially regarding the specific influence of sex steroid hormones in gender differences. Further experimental or clinical investigations are necessary to elucidate gender differences in cardiac repolarization, QT interval prolongation, and susceptibility to cardiac arrhythmias.",
author = "Yang, {Pei Chi} and Clancy, {Colleen E}",
year = "2010",
month = "8",
doi = "10.1097/FJC.0b013e3181d6f7dd",
language = "English (US)",
volume = "56",
pages = "123--129",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Effects of sex hormones on cardiac repolarization

AU - Yang, Pei Chi

AU - Clancy, Colleen E

PY - 2010/8

Y1 - 2010/8

N2 - This article reviews the current findings on the topic of gender differences derived from effects of sex steroid hormones on cardiac repolarization and drug-induced torsade de pointes. Published studies have shown that sex-related differences exist in clinical cardiac electrophysiologic measurements, and that gender is an independent risk factor in vulnerability to certain types of arrhythmia. For example, women are especially susceptible to increased arrhythmia risk in response to QT-prolonging drugs. However, a number of questions remain-especially regarding the specific influence of sex steroid hormones in gender differences. Further experimental or clinical investigations are necessary to elucidate gender differences in cardiac repolarization, QT interval prolongation, and susceptibility to cardiac arrhythmias.

AB - This article reviews the current findings on the topic of gender differences derived from effects of sex steroid hormones on cardiac repolarization and drug-induced torsade de pointes. Published studies have shown that sex-related differences exist in clinical cardiac electrophysiologic measurements, and that gender is an independent risk factor in vulnerability to certain types of arrhythmia. For example, women are especially susceptible to increased arrhythmia risk in response to QT-prolonging drugs. However, a number of questions remain-especially regarding the specific influence of sex steroid hormones in gender differences. Further experimental or clinical investigations are necessary to elucidate gender differences in cardiac repolarization, QT interval prolongation, and susceptibility to cardiac arrhythmias.

UR - http://www.scopus.com/inward/record.url?scp=77955958017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955958017&partnerID=8YFLogxK

U2 - 10.1097/FJC.0b013e3181d6f7dd

DO - 10.1097/FJC.0b013e3181d6f7dd

M3 - Article

C2 - 20164789

AN - SCOPUS:77955958017

VL - 56

SP - 123

EP - 129

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 2

ER -