Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horses

Eugene Steffey, Khursheed R. Mama, Frank D. Galey, Birgit Puschner, Michael J. Woliner

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective - To quantitate effects of dose of sevoflurane and mode of ventilation on cardiovascular and respiratory function in horses and identify changes in serum biochemical values associated with sevoflurane anesthesia. Animals - 6 healthy adult horses. Procedure - Horses were anesthetized twice: first, to determine the minimum alveolar concentration (MAC) of sevoflurane and second, to characterize cardiopulmonary and serum biochemical responses of horses to 1.0, 1.5, and 1.75 MAC multiples of sevoflurane during controlled and spontaneous ventilation. Results - Mean (± SEM) MAC of sevoflurane was 2.84 ± 0.16%. Cardiovascular performance during anesthesia decreased as sevoflurane dose increased; the magnitude of cardiovascular depression was more severe during mechanical ventilation, compared with spontaneous ventilation. Serum inorganic fluoride concentration increased to a peak of 50.8 ± 7.1 μmol/L at the end of anesthesia. Serum creatinine concentration and sorbitol dehydrogenase activity reached their greatest values (2.0 ± 0.8 mg/dL and 10.2 ± 1.8 U/L, respectively) at 1 hour after anesthesia and then returned to baseline by 1 day after anesthesia. Serum creatine kinase, aspartate aminotransferase, and alkaline phosphatase activities reached peak values by the first (ie, creatine kinase) or second (ie, aspartate aminotransferase and alkaline phosphatase) day after anesthesia. Conclusions and clinical relevance - Sevoflurane causes dose-related cardiopulmonary depression, and mode of ventilation further impacts the magnitude of this depression. Except for serum inorganic fluoride concentration, quantitative alterations in serum biochemical indices of liver- and muscle-cell disruption and kidney function were considered clinically unremarkable and similar to results from comparable studies of other inhalation anesthetics.

Original languageEnglish (US)
Pages (from-to)606-614
Number of pages9
JournalAmerican Journal of Veterinary Research
Volume66
Issue number4
DOIs
StatePublished - Apr 2005

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blood serum
Horses
Ventilation
anesthesia
Anesthesia
horses
blood
dosage
Serum
creatine kinase
Creatine Kinase
fluorides
Aspartate Aminotransferases
Fluorides
aspartate transaminase
Alkaline Phosphatase
alkaline phosphatase
L-iditol dehydrogenase
L-Iditol 2-Dehydrogenase
Inhalation Anesthetics

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horses. / Steffey, Eugene; Mama, Khursheed R.; Galey, Frank D.; Puschner, Birgit; Woliner, Michael J.

In: American Journal of Veterinary Research, Vol. 66, No. 4, 04.2005, p. 606-614.

Research output: Contribution to journalArticle

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abstract = "Objective - To quantitate effects of dose of sevoflurane and mode of ventilation on cardiovascular and respiratory function in horses and identify changes in serum biochemical values associated with sevoflurane anesthesia. Animals - 6 healthy adult horses. Procedure - Horses were anesthetized twice: first, to determine the minimum alveolar concentration (MAC) of sevoflurane and second, to characterize cardiopulmonary and serum biochemical responses of horses to 1.0, 1.5, and 1.75 MAC multiples of sevoflurane during controlled and spontaneous ventilation. Results - Mean (± SEM) MAC of sevoflurane was 2.84 ± 0.16{\%}. Cardiovascular performance during anesthesia decreased as sevoflurane dose increased; the magnitude of cardiovascular depression was more severe during mechanical ventilation, compared with spontaneous ventilation. Serum inorganic fluoride concentration increased to a peak of 50.8 ± 7.1 μmol/L at the end of anesthesia. Serum creatinine concentration and sorbitol dehydrogenase activity reached their greatest values (2.0 ± 0.8 mg/dL and 10.2 ± 1.8 U/L, respectively) at 1 hour after anesthesia and then returned to baseline by 1 day after anesthesia. Serum creatine kinase, aspartate aminotransferase, and alkaline phosphatase activities reached peak values by the first (ie, creatine kinase) or second (ie, aspartate aminotransferase and alkaline phosphatase) day after anesthesia. Conclusions and clinical relevance - Sevoflurane causes dose-related cardiopulmonary depression, and mode of ventilation further impacts the magnitude of this depression. Except for serum inorganic fluoride concentration, quantitative alterations in serum biochemical indices of liver- and muscle-cell disruption and kidney function were considered clinically unremarkable and similar to results from comparable studies of other inhalation anesthetics.",
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