Effects of scatter on model parameter estimates in 3D PET studies of the human brain

Simon R. Cherry, Sung Cheng Huang

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


The effects of scatter 3D PET projection data, reconstructed images and model parameter estimates are characterized using phantom measurements and simulation data. Scatter distributions are estimated from studies of the 3D Hoffman brain phantom by the 2D/3D difference method. Results show that the total scatter fraction in the projection data is 40%, but reduces to 27% when only those counts within the boundary of the brain are considered. After reconstruction, the whole brain scatter fraction is 20%, averaging 10% in the cortical gray matter, 21% in basal ganglia and 40% in white matter. The scatter contribution varies by almost a factor of two from the edge to the center of the brain due to the shape of the scatter distribution and the effects of attenuation correction.

Original languageEnglish (US)
Pages (from-to)1174-1179
Number of pages6
JournalIEEE Transactions on Nuclear Science
Issue number4 pt 1
StatePublished - Aug 1995
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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