Effects of propargylic substitution and annelation on the cycloaromatization of a Bicyclo[7.3.1] enediyne

David K. Moss, John D. Spence, Michael H. Nantz

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The cycloaromatization kinetics of two bicyclo[7.3.1] enediynes are presented. Silyl protection of a propargylic alcohol positioned on the enediyne core was found to moderate enediyne cycloaromatization. However, the presence of multiple fused ring systems exerts geometrical constraints that prevent cycloaromatization of the otherwise facile cyclization previously observed for the core system.

Original languageEnglish (US)
Pages (from-to)4339-4343
Number of pages5
JournalJournal of Organic Chemistry
Volume64
Issue number12
DOIs
StatePublished - Jun 11 1999

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Effects of propargylic substitution and annelation on the cycloaromatization of a Bicyclo[7.3.1] enediyne'. Together they form a unique fingerprint.

  • Cite this