Effects of prolactin on hematopoiesis

L. A. Welniak, S. M. Richards, William J Murphy

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The presence of extra-pituitary prolactin and its cognitive receptors in the hematopoietic micro-environment raises the question of whether prolactin plays a role in lympho-hematopoiesis and under what conditions. Current studies suggest that endogenous prolactin does not play a significant role under normal steady-state conditions. Rather, prolactin has been implicated as a 'stress hormone', functioning to restore hematopoietic homeostasis under conditions of dysregulation. The stress response of prolactin as well as its complex relationship with other hormones and factors has resulted in conflicting reports in the literature regarding prolactin's role in lympho-hematopoiesis. A review of this literature is provided as well as discussion of conditions under which lympho-hematopoietic activity of prolactin may be evident.

Original languageEnglish (US)
Pages (from-to)700-705
Number of pages6
JournalLupus
Volume10
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Erythroid
  • Lymphopoiesis
  • Myeloid
  • Prolactin
  • Transplantation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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