Abstract
This study examined the effects of prenatal ethanol exposure on hippocampal theta activity in adult rats. Subjects were randomly selected from four prenatal treatment conditions: untreated, 0, 3, or 5 g/kg/day ethanol. At approximately 90 days of age, all subjects were surgically implanted with a bipolar electrode in the CA1 region of the hippocampus. Four epochs of hippocampal theta rhythm activity were recorded while the subjects were moving and four more while still, and a normalized theta score was computed and compared among groups. The 5 g/kg male group demonstrated a significantly higher theta score than controls, indicating either an increase in type I (movement-associated) theta and/or a decrease in type II (information-processing) theta activity. These results are consistent with prior reports that prenatal ethanol exposure alters hippocampal function and support clinical indications that monitoring the EEG of children may prove to be useful in the diagnosis of fetal alcohol syndrome and/or the detection of alcohol-related birth defects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 231-235 |
| Number of pages | 5 |
| Journal | Alcohol |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1997 |
| Externally published | Yes |
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Keywords
- Alcohol
- EEG
- FAS
- Fetal alcohol syndrome
- Hippocampus
- Theta rhythm
ASJC Scopus subject areas
- Biochemistry
- Medicine(all)
- Behavioral Neuroscience
- Neuroscience(all)
- Toxicology
- Health(social science)
Cite this
Effects of prenatal ethanol exposure on hippocampal theta activity in the rat. / Cortese, Bernadette M.; Krahl, Scott E.; Berman, Robert F; Hannigan, John H.
In: Alcohol, Vol. 14, No. 3, 05.1997, p. 231-235.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of prenatal ethanol exposure on hippocampal theta activity in the rat
AU - Cortese, Bernadette M.
AU - Krahl, Scott E.
AU - Berman, Robert F
AU - Hannigan, John H.
PY - 1997/5
Y1 - 1997/5
N2 - This study examined the effects of prenatal ethanol exposure on hippocampal theta activity in adult rats. Subjects were randomly selected from four prenatal treatment conditions: untreated, 0, 3, or 5 g/kg/day ethanol. At approximately 90 days of age, all subjects were surgically implanted with a bipolar electrode in the CA1 region of the hippocampus. Four epochs of hippocampal theta rhythm activity were recorded while the subjects were moving and four more while still, and a normalized theta score was computed and compared among groups. The 5 g/kg male group demonstrated a significantly higher theta score than controls, indicating either an increase in type I (movement-associated) theta and/or a decrease in type II (information-processing) theta activity. These results are consistent with prior reports that prenatal ethanol exposure alters hippocampal function and support clinical indications that monitoring the EEG of children may prove to be useful in the diagnosis of fetal alcohol syndrome and/or the detection of alcohol-related birth defects.
AB - This study examined the effects of prenatal ethanol exposure on hippocampal theta activity in adult rats. Subjects were randomly selected from four prenatal treatment conditions: untreated, 0, 3, or 5 g/kg/day ethanol. At approximately 90 days of age, all subjects were surgically implanted with a bipolar electrode in the CA1 region of the hippocampus. Four epochs of hippocampal theta rhythm activity were recorded while the subjects were moving and four more while still, and a normalized theta score was computed and compared among groups. The 5 g/kg male group demonstrated a significantly higher theta score than controls, indicating either an increase in type I (movement-associated) theta and/or a decrease in type II (information-processing) theta activity. These results are consistent with prior reports that prenatal ethanol exposure alters hippocampal function and support clinical indications that monitoring the EEG of children may prove to be useful in the diagnosis of fetal alcohol syndrome and/or the detection of alcohol-related birth defects.
KW - Alcohol
KW - EEG
KW - FAS
KW - Fetal alcohol syndrome
KW - Hippocampus
KW - Theta rhythm
UR - http://www.scopus.com/inward/record.url?scp=0030996083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030996083&partnerID=8YFLogxK
U2 - 10.1016/S0741-8329(96)00147-4
DO - 10.1016/S0741-8329(96)00147-4
M3 - Article
C2 - 9160800
AN - SCOPUS:0030996083
VL - 14
SP - 231
EP - 235
JO - Alcohol
JF - Alcohol
SN - 0741-8329
IS - 3
ER -