Effects of polysulfated glycosaminoglycans on articular cartilage in a Pond-Nuki model of osteoarthritis

D. L. Korvick, D. L. Millis, C. F. Zhu, C. M. Agrawal, K. A. Athanasiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polysulfated glycosaminoglycans (PSGAG) as chondroprotective agents are popular ways to spare the cartilage from matrix loss. The matrix loss is due to the effects of cranial cruciate ligament (CCL) transection which leads to the release of cytokines and proteases from synovium and chondrocytes. A study is conducted to determine the effectivity of the cartilage matrix loss prevention by PSGAG. The cranial and caudal sites respond differently to the ligament transection. The cranial site undergoes reduction in HA as a result of CCL transection. Treatments with PSGAG do not prevent cartilage softening due to the CCL transection.

Original languageEnglish (US)
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages137
Number of pages1
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

ASJC Scopus subject areas

  • Engineering(all)

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    Korvick, D. L., Millis, D. L., Zhu, C. F., Agrawal, C. M., & Athanasiou, K. A. (1998). Effects of polysulfated glycosaminoglycans on articular cartilage in a Pond-Nuki model of osteoarthritis. In Southern Biomedical Engineering Conference - Proceedings (pp. 137). IEEE.