Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study

Anthony T W Cheung, Matthew S. Chan, Sahana Ramanujam, Arun Rangaswami, Kris Curl, Patricia Franklin, Theodore Wun

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Nine patients with sickle cell disease (SCD) who were hospitalized at UC Davis Medical Center for vaso-occlusive crisis (VOC) were studied as part of a randomized double-blind phase III clinical trial to investigate the real-time effects of poloxamer 188 on VOC. All patients showed significant microvascular changes from normal (steady-state) values during VOC (diminished venular diameter and red cell velocity). The patients were randomly assigned to be treated with poloxamer 188 or placebo. Poloxamer 188 (n = 4) but not placebo (n = 5) significantly reversed these microvascular changes ∼ 2 hours postinitiation of loading infusion (100 mg/kg in 1 hour). Further significant improvement induced by poloxamer 188 but not placebo was observed > 7 hours postinfusion, resulting in a significant reversal of the microvascular changes to steady-state values.

Original languageEnglish (US)
Pages (from-to)402-406
Number of pages5
JournalJournal of Investigative Medicine
Volume52
Issue number6
StatePublished - Sep 2004

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Poloxamer
Placebos
Phase III Clinical Trials
Sickle Cell Anemia
Therapeutics
Cells
Intravital Microscopy

Keywords

  • Microcirculation
  • Poloxamer 188
  • Sickle cell crisis
  • Vaso-occlusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cheung, A. T. W., Chan, M. S., Ramanujam, S., Rangaswami, A., Curl, K., Franklin, P., & Wun, T. (2004). Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study. Journal of Investigative Medicine, 52(6), 402-406.

Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis : Computer-assisted intravital microscopy study. / Cheung, Anthony T W; Chan, Matthew S.; Ramanujam, Sahana; Rangaswami, Arun; Curl, Kris; Franklin, Patricia; Wun, Theodore.

In: Journal of Investigative Medicine, Vol. 52, No. 6, 09.2004, p. 402-406.

Research output: Contribution to journalArticle

Cheung, ATW, Chan, MS, Ramanujam, S, Rangaswami, A, Curl, K, Franklin, P & Wun, T 2004, 'Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study', Journal of Investigative Medicine, vol. 52, no. 6, pp. 402-406.
Cheung ATW, Chan MS, Ramanujam S, Rangaswami A, Curl K, Franklin P et al. Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study. Journal of Investigative Medicine. 2004 Sep;52(6):402-406.
Cheung, Anthony T W ; Chan, Matthew S. ; Ramanujam, Sahana ; Rangaswami, Arun ; Curl, Kris ; Franklin, Patricia ; Wun, Theodore. / Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis : Computer-assisted intravital microscopy study. In: Journal of Investigative Medicine. 2004 ; Vol. 52, No. 6. pp. 402-406.
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