Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study

Anthony T W Cheung, Matthew S. Chan, Sahana Ramanujam, Arun Rangaswami, Kris Curl, Patricia Franklin, Theodore Wun

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Nine patients with sickle cell disease (SCD) who were hospitalized at UC Davis Medical Center for vaso-occlusive crisis (VOC) were studied as part of a randomized double-blind phase III clinical trial to investigate the real-time effects of poloxamer 188 on VOC. All patients showed significant microvascular changes from normal (steady-state) values during VOC (diminished venular diameter and red cell velocity). The patients were randomly assigned to be treated with poloxamer 188 or placebo. Poloxamer 188 (n = 4) but not placebo (n = 5) significantly reversed these microvascular changes ∼ 2 hours postinitiation of loading infusion (100 mg/kg in 1 hour). Further significant improvement induced by poloxamer 188 but not placebo was observed > 7 hours postinfusion, resulting in a significant reversal of the microvascular changes to steady-state values.

Original languageEnglish (US)
Pages (from-to)402-406
Number of pages5
JournalJournal of Investigative Medicine
Volume52
Issue number6
StatePublished - Sep 2004

Keywords

  • Microcirculation
  • Poloxamer 188
  • Sickle cell crisis
  • Vaso-occlusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Cheung, A. T. W., Chan, M. S., Ramanujam, S., Rangaswami, A., Curl, K., Franklin, P., & Wun, T. (2004). Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study. Journal of Investigative Medicine, 52(6), 402-406.