Abstract
We used both intracellular and field potential recordings to study the effects of phenytoin (20 to 40 μg per milliliter) on CA3 and CA1 neurons of guinea pig hippocampal slices, with or without exposure to convulsant sodium penicillin G. Phenytoin did not change resting membrane potential, input resistance, action potential amplitude or duration, or the threshold intensity for activating action potentials or bursts with intracellular current pulses. Suppression of penicillin-induced bursting was associated with an increased threshold for orthodromically activating neurons. The intrinsic bursting mechanisms of the cells remained intact. Phenytoin seemed to suppress penicillin-induced epileptiform activity by decreasing synaptic transmission.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 730-738 |
| Number of pages | 9 |
| Journal | Neurology |
| Volume | 32 |
| Issue number | 7 |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Effects of phenytoin on normal activity and on penicillin-induced bursting in the guinea pig hippocampal slice. / Schneiderman, J. H.; Schwartzkroin, Philip A.
In: Neurology, Vol. 32, No. 7, 1982, p. 730-738.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of phenytoin on normal activity and on penicillin-induced bursting in the guinea pig hippocampal slice
AU - Schneiderman, J. H.
AU - Schwartzkroin, Philip A
PY - 1982
Y1 - 1982
N2 - We used both intracellular and field potential recordings to study the effects of phenytoin (20 to 40 μg per milliliter) on CA3 and CA1 neurons of guinea pig hippocampal slices, with or without exposure to convulsant sodium penicillin G. Phenytoin did not change resting membrane potential, input resistance, action potential amplitude or duration, or the threshold intensity for activating action potentials or bursts with intracellular current pulses. Suppression of penicillin-induced bursting was associated with an increased threshold for orthodromically activating neurons. The intrinsic bursting mechanisms of the cells remained intact. Phenytoin seemed to suppress penicillin-induced epileptiform activity by decreasing synaptic transmission.
AB - We used both intracellular and field potential recordings to study the effects of phenytoin (20 to 40 μg per milliliter) on CA3 and CA1 neurons of guinea pig hippocampal slices, with or without exposure to convulsant sodium penicillin G. Phenytoin did not change resting membrane potential, input resistance, action potential amplitude or duration, or the threshold intensity for activating action potentials or bursts with intracellular current pulses. Suppression of penicillin-induced bursting was associated with an increased threshold for orthodromically activating neurons. The intrinsic bursting mechanisms of the cells remained intact. Phenytoin seemed to suppress penicillin-induced epileptiform activity by decreasing synaptic transmission.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019976053&partnerID=8YFLogxK
M3 - Article
C2 - 6283425
AN - SCOPUS:0019976053
VL - 32
SP - 730
EP - 738
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 7
ER -