Effects of palmitate on astrocyte amino acid contents

Marc Yudkoff, Itzhak Nissim, Ilana Nissim, Janet Stern, David E Pleasure

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The effects of palmitate on intracellular and extracellular amino acid concentrations of cultured astrocytes was studied. Exposure of astrocytes to either 0.72 mM or 0.36 mM palmitate was associated with a significant reduction in the intracellular pool of glutamine and taurine. In contrast, the intracellular concentration of histidine, glycine, citrulline, isoleucine and leucine were increased in the presence of 0.72 mM palmitate. Comparable changes in the extracellular amino acid pool were not observed. The data suggest that palmitic acid, which accumulates in the brain during periods of anoxia, alters the metabolism of several amino acids in cultured astrocytes. These changes may be of significance in terms of the pathophysiology of a stress such as anoxia.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalNeurochemical Research
Volume14
Issue number4
DOIs
StatePublished - Apr 1989
Externally publishedYes

Keywords

  • amino acids
  • anoxia
  • astrocytes
  • Palmitate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

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