Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus)

Caroline M. Hostetler, Katherine Hinde, Nicole Maninger, Sally P. Mendoza, William A. Mason, Douglas J. Rowland, Guobao Wang, David Kukis, Simon R Cherry, Karen L. Bales

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pair bonding leads to increases in dopamine D1 receptor (D1R) binding in the nucleus accumbens of monogamous prairie voles. In the current study, we hypothesized that there is similar up-regulation of D1R in a monogamous primate, the titi monkey (Callicebus cupreus). Receptor binding of the D1R antagonist [11C]-SCH23390 was measured in male titi monkeys using PET scans before and after pairing with a female. We found that within-subject analyses of pairing show significant increases in D1R binding in the lateral septum, but not the nucleus accumbens, caudate, putamen, or ventral pallidum. The lateral septum is involved in a number of processes that may contribute to social behavior, including motivation, affect, reward, and reinforcement. This region also plays a role in pair bonding and paternal behavior in voles. Our observations of changes in D1R in the lateral septum, but not the nucleus accumbens, suggest that there may be broadly similar dopaminergic mechanisms underlying pair bonding across mammalian species, but that the specific changes to neural circuitry differ. This study is the first research to demonstrate neuroplasticity of the dopamine system following pair bonding in a non-human primate; however, substantial variability in the response to pairing suggests the utility of further research on the topic.

Original languageEnglish (US)
JournalAmerican Journal of Primatology
DOIs
StateAccepted/In press - 2016

Fingerprint

attachment behavior
dopamine
primate
monkeys
receptors
social behavior
prairie
reinforcement
Primates
paternal behavior
Microtus ochrogaster
positron-emission tomography
effect
antagonists
regulation

Keywords

  • Attachment
  • Dopamine receptor
  • Lateral septum
  • Monogamy
  • Titi monkey

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

Cite this

Hostetler, C. M., Hinde, K., Maninger, N., Mendoza, S. P., Mason, W. A., Rowland, D. J., ... Bales, K. L. (Accepted/In press). Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus). American Journal of Primatology. https://doi.org/10.1002/ajp.22612

Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus). / Hostetler, Caroline M.; Hinde, Katherine; Maninger, Nicole; Mendoza, Sally P.; Mason, William A.; Rowland, Douglas J.; Wang, Guobao; Kukis, David; Cherry, Simon R; Bales, Karen L.

In: American Journal of Primatology, 2016.

Research output: Contribution to journalArticle

Hostetler, Caroline M. ; Hinde, Katherine ; Maninger, Nicole ; Mendoza, Sally P. ; Mason, William A. ; Rowland, Douglas J. ; Wang, Guobao ; Kukis, David ; Cherry, Simon R ; Bales, Karen L. / Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus). In: American Journal of Primatology. 2016.
@article{ae8ef9259e5c400888d27d818aae67fb,
title = "Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus)",
abstract = "Pair bonding leads to increases in dopamine D1 receptor (D1R) binding in the nucleus accumbens of monogamous prairie voles. In the current study, we hypothesized that there is similar up-regulation of D1R in a monogamous primate, the titi monkey (Callicebus cupreus). Receptor binding of the D1R antagonist [11C]-SCH23390 was measured in male titi monkeys using PET scans before and after pairing with a female. We found that within-subject analyses of pairing show significant increases in D1R binding in the lateral septum, but not the nucleus accumbens, caudate, putamen, or ventral pallidum. The lateral septum is involved in a number of processes that may contribute to social behavior, including motivation, affect, reward, and reinforcement. This region also plays a role in pair bonding and paternal behavior in voles. Our observations of changes in D1R in the lateral septum, but not the nucleus accumbens, suggest that there may be broadly similar dopaminergic mechanisms underlying pair bonding across mammalian species, but that the specific changes to neural circuitry differ. This study is the first research to demonstrate neuroplasticity of the dopamine system following pair bonding in a non-human primate; however, substantial variability in the response to pairing suggests the utility of further research on the topic.",
keywords = "Attachment, Dopamine receptor, Lateral septum, Monogamy, Titi monkey",
author = "Hostetler, {Caroline M.} and Katherine Hinde and Nicole Maninger and Mendoza, {Sally P.} and Mason, {William A.} and Rowland, {Douglas J.} and Guobao Wang and David Kukis and Cherry, {Simon R} and Bales, {Karen L.}",
year = "2016",
doi = "10.1002/ajp.22612",
language = "English (US)",
journal = "American Journal of Primatology",
issn = "0275-2565",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus)

AU - Hostetler, Caroline M.

AU - Hinde, Katherine

AU - Maninger, Nicole

AU - Mendoza, Sally P.

AU - Mason, William A.

AU - Rowland, Douglas J.

AU - Wang, Guobao

AU - Kukis, David

AU - Cherry, Simon R

AU - Bales, Karen L.

PY - 2016

Y1 - 2016

N2 - Pair bonding leads to increases in dopamine D1 receptor (D1R) binding in the nucleus accumbens of monogamous prairie voles. In the current study, we hypothesized that there is similar up-regulation of D1R in a monogamous primate, the titi monkey (Callicebus cupreus). Receptor binding of the D1R antagonist [11C]-SCH23390 was measured in male titi monkeys using PET scans before and after pairing with a female. We found that within-subject analyses of pairing show significant increases in D1R binding in the lateral septum, but not the nucleus accumbens, caudate, putamen, or ventral pallidum. The lateral septum is involved in a number of processes that may contribute to social behavior, including motivation, affect, reward, and reinforcement. This region also plays a role in pair bonding and paternal behavior in voles. Our observations of changes in D1R in the lateral septum, but not the nucleus accumbens, suggest that there may be broadly similar dopaminergic mechanisms underlying pair bonding across mammalian species, but that the specific changes to neural circuitry differ. This study is the first research to demonstrate neuroplasticity of the dopamine system following pair bonding in a non-human primate; however, substantial variability in the response to pairing suggests the utility of further research on the topic.

AB - Pair bonding leads to increases in dopamine D1 receptor (D1R) binding in the nucleus accumbens of monogamous prairie voles. In the current study, we hypothesized that there is similar up-regulation of D1R in a monogamous primate, the titi monkey (Callicebus cupreus). Receptor binding of the D1R antagonist [11C]-SCH23390 was measured in male titi monkeys using PET scans before and after pairing with a female. We found that within-subject analyses of pairing show significant increases in D1R binding in the lateral septum, but not the nucleus accumbens, caudate, putamen, or ventral pallidum. The lateral septum is involved in a number of processes that may contribute to social behavior, including motivation, affect, reward, and reinforcement. This region also plays a role in pair bonding and paternal behavior in voles. Our observations of changes in D1R in the lateral septum, but not the nucleus accumbens, suggest that there may be broadly similar dopaminergic mechanisms underlying pair bonding across mammalian species, but that the specific changes to neural circuitry differ. This study is the first research to demonstrate neuroplasticity of the dopamine system following pair bonding in a non-human primate; however, substantial variability in the response to pairing suggests the utility of further research on the topic.

KW - Attachment

KW - Dopamine receptor

KW - Lateral septum

KW - Monogamy

KW - Titi monkey

UR - http://www.scopus.com/inward/record.url?scp=84995443077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995443077&partnerID=8YFLogxK

U2 - 10.1002/ajp.22612

DO - 10.1002/ajp.22612

M3 - Article

JO - American Journal of Primatology

JF - American Journal of Primatology

SN - 0275-2565

ER -