Effects of ozone on lung and somatic growth. Pair fed rats after ozone exposure and recovery periods

Walter S. Tyler, Nancy K. Tyler, Jerold A Last, Thomas J. Barstow, David J. Magliano, Dave M. Hinds

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Minor differences in lung growth and development during childhood have been considered as a potential cause of rapid decline in pulmonary function in adulthood. Inhalation of ozone commonly causes changes in both body weight and lung volumes, which complicates interpretation of any changes in lung growth. The effects of ozone on lung growth were studied in rats which were pair fed. This technique permitted comparison of ozone-exposed and filtered-air control rats of the same body weight and body size as well as age and sex. Exposure was to filtered air or to 0.64 or 0.96 ppm ozone (UV standard) 8 h/night for 42 nights. A second control group was fed ad libitum and exposed to only filtered air. Half the rats were studied at the end of the 42-night exposures, the rest after a 42-day post-exposure period during which all rats were fed ad libitum and breathed filtered air. Rats examined at the end of the exposure period had larger saline and fixed lung volumes. These larger lungs had greater volumes of parenchyma, alveoli and respiratory bronchioles. Some of these changes persisted throughout a 42-day post-exposure period. Ozone inhalation by young rats alters lung growth and development in ways likely to be detrimental and those changes persist after ozone inhalation stops.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalToxicology
Volume46
Issue number1
DOIs
StatePublished - Oct 12 1987

Fingerprint

Ozone
Rats
Recovery
Lung
Growth
Air
Inhalation
Growth and Development
Rat control
Body Weight
Bronchioles
Body Size
Control Groups

Keywords

  • Compliance
  • Lung growth
  • Morphometry
  • Ozone
  • Rat
  • Scanning electron microscopy
  • Somatic growth

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of ozone on lung and somatic growth. Pair fed rats after ozone exposure and recovery periods. / Tyler, Walter S.; Tyler, Nancy K.; Last, Jerold A; Barstow, Thomas J.; Magliano, David J.; Hinds, Dave M.

In: Toxicology, Vol. 46, No. 1, 12.10.1987, p. 1-20.

Research output: Contribution to journalArticle

Tyler, Walter S. ; Tyler, Nancy K. ; Last, Jerold A ; Barstow, Thomas J. ; Magliano, David J. ; Hinds, Dave M. / Effects of ozone on lung and somatic growth. Pair fed rats after ozone exposure and recovery periods. In: Toxicology. 1987 ; Vol. 46, No. 1. pp. 1-20.
@article{065adfadf1c34b1681e6fd17661e5c3a,
title = "Effects of ozone on lung and somatic growth. Pair fed rats after ozone exposure and recovery periods",
abstract = "Minor differences in lung growth and development during childhood have been considered as a potential cause of rapid decline in pulmonary function in adulthood. Inhalation of ozone commonly causes changes in both body weight and lung volumes, which complicates interpretation of any changes in lung growth. The effects of ozone on lung growth were studied in rats which were pair fed. This technique permitted comparison of ozone-exposed and filtered-air control rats of the same body weight and body size as well as age and sex. Exposure was to filtered air or to 0.64 or 0.96 ppm ozone (UV standard) 8 h/night for 42 nights. A second control group was fed ad libitum and exposed to only filtered air. Half the rats were studied at the end of the 42-night exposures, the rest after a 42-day post-exposure period during which all rats were fed ad libitum and breathed filtered air. Rats examined at the end of the exposure period had larger saline and fixed lung volumes. These larger lungs had greater volumes of parenchyma, alveoli and respiratory bronchioles. Some of these changes persisted throughout a 42-day post-exposure period. Ozone inhalation by young rats alters lung growth and development in ways likely to be detrimental and those changes persist after ozone inhalation stops.",
keywords = "Compliance, Lung growth, Morphometry, Ozone, Rat, Scanning electron microscopy, Somatic growth",
author = "Tyler, {Walter S.} and Tyler, {Nancy K.} and Last, {Jerold A} and Barstow, {Thomas J.} and Magliano, {David J.} and Hinds, {Dave M.}",
year = "1987",
month = "10",
day = "12",
doi = "10.1016/0300-483X(87)90133-8",
language = "English (US)",
volume = "46",
pages = "1--20",
journal = "Toxicology",
issn = "0300-483X",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Effects of ozone on lung and somatic growth. Pair fed rats after ozone exposure and recovery periods

AU - Tyler, Walter S.

AU - Tyler, Nancy K.

AU - Last, Jerold A

AU - Barstow, Thomas J.

AU - Magliano, David J.

AU - Hinds, Dave M.

PY - 1987/10/12

Y1 - 1987/10/12

N2 - Minor differences in lung growth and development during childhood have been considered as a potential cause of rapid decline in pulmonary function in adulthood. Inhalation of ozone commonly causes changes in both body weight and lung volumes, which complicates interpretation of any changes in lung growth. The effects of ozone on lung growth were studied in rats which were pair fed. This technique permitted comparison of ozone-exposed and filtered-air control rats of the same body weight and body size as well as age and sex. Exposure was to filtered air or to 0.64 or 0.96 ppm ozone (UV standard) 8 h/night for 42 nights. A second control group was fed ad libitum and exposed to only filtered air. Half the rats were studied at the end of the 42-night exposures, the rest after a 42-day post-exposure period during which all rats were fed ad libitum and breathed filtered air. Rats examined at the end of the exposure period had larger saline and fixed lung volumes. These larger lungs had greater volumes of parenchyma, alveoli and respiratory bronchioles. Some of these changes persisted throughout a 42-day post-exposure period. Ozone inhalation by young rats alters lung growth and development in ways likely to be detrimental and those changes persist after ozone inhalation stops.

AB - Minor differences in lung growth and development during childhood have been considered as a potential cause of rapid decline in pulmonary function in adulthood. Inhalation of ozone commonly causes changes in both body weight and lung volumes, which complicates interpretation of any changes in lung growth. The effects of ozone on lung growth were studied in rats which were pair fed. This technique permitted comparison of ozone-exposed and filtered-air control rats of the same body weight and body size as well as age and sex. Exposure was to filtered air or to 0.64 or 0.96 ppm ozone (UV standard) 8 h/night for 42 nights. A second control group was fed ad libitum and exposed to only filtered air. Half the rats were studied at the end of the 42-night exposures, the rest after a 42-day post-exposure period during which all rats were fed ad libitum and breathed filtered air. Rats examined at the end of the exposure period had larger saline and fixed lung volumes. These larger lungs had greater volumes of parenchyma, alveoli and respiratory bronchioles. Some of these changes persisted throughout a 42-day post-exposure period. Ozone inhalation by young rats alters lung growth and development in ways likely to be detrimental and those changes persist after ozone inhalation stops.

KW - Compliance

KW - Lung growth

KW - Morphometry

KW - Ozone

KW - Rat

KW - Scanning electron microscopy

KW - Somatic growth

UR - http://www.scopus.com/inward/record.url?scp=0023231478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023231478&partnerID=8YFLogxK

U2 - 10.1016/0300-483X(87)90133-8

DO - 10.1016/0300-483X(87)90133-8

M3 - Article

C2 - 3660417

AN - SCOPUS:0023231478

VL - 46

SP - 1

EP - 20

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 1

ER -