Effects of ovarian steroids on immunoglobulin-secreting cell function in healthy women

Fabien X. Lü, Zhongmin Ma, Susie Moser, Thomas G. Evans, Chris J Miller

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

To determine the effect of the ovarian hormone cycle on immunity; immunoglobulin-secreting cell (ISC) frequency and lymphocyte subsets were examined in the blood of healthy women. We found that immunoglobulin A (IgA)-secreting cells (IgA-ISC) were fourfold more frequent than IgG-ISC in peripheral blood mononuclear cells (PBMC). Further, the ISC frequency in PBMC was highest (P < 0.05) during the periovulatory stage of the menstrual cycle. Thus, endogenous ovarian steroids regulate the ISC frequency and this may explain why women are more resistant to viral infections and tend to have more immune-mediated diseases than men do.

Original languageEnglish (US)
Pages (from-to)944-949
Number of pages6
JournalClinical and Diagnostic Laboratory Immunology
Volume10
Issue number5
DOIs
StatePublished - Sep 2003

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Clinical Biochemistry
  • Immunology

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