Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: A randomized controlled trial

Christina E. West, Anne Staudt Kvistgaard, Janet M. Peerson, Sharon M. Donovan, Yong Mei Peng, Bo Lönnerdal

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

BackgroundHuman milk is rich in osteopontin (OPN), which has immunomodulatory functions.MethodsIn a randomized controlled trial, standard formula (SF) and the same formula with 65 mg of OPN/L (F65) or 130 mg of OPN/L (F130), representing ∼50 and 100% of the OPN concentration in human milk, were compared. We examined frequencies and composition of peripheral blood immune cells by four-color immunoflow cytometry of formula-fed infants at ages 1, 4, and 6 months, and compared them with a breastfed (BF) reference group.ResultsThe F130 group had increased T-cell proportions compared with the SF (P=0.036, average effect size 0.51) and F65 groups (P=0.008, average effect size 0.65). Compared with the BF group, the monocyte proportions were increased in the F65 (P=0.001, average effect size 0.59) and F130 (P=0.006, average effect size 0.50) groups, but were comparable among the formula groups.ConclusionOPN in an infant formula at a concentration close to that of human milk increased the proportion of circulating T cells compared with both SF and formula with added OPN at ∼50% of the concentration in human milk. This suggests that OPN may favorably influence immune ontogeny in infancy and that the effects appear to be dose-dependent.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalPediatric Research
Volume82
Issue number1
DOIs
StatePublished - Jul 1 2017

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    West, C. E., Kvistgaard, A. S., Peerson, J. M., Donovan, S. M., Peng, Y. M., & Lönnerdal, B. (2017). Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: A randomized controlled trial. Pediatric Research, 82(1), 63-71. https://doi.org/10.1038/pr.2017.77